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Message definition (GLP-1 receptor agonist ) ===Obesity=== GLP-1 agonists are recommended as an add-on therapy to lifestyle intervention (calorie restriction and exercise) in people with a [[Body mass index|BMI]] over 30 or a BMI over 27 with at least one weight-related comorbidity. Although some GLP-1 agonists such as semaglutide are more effective than other weight loss drugs, they are still less effective than [[bariatric surgery]] in causing weight loss. GLP-1 agonists' weight reduction effects come from a combination of peripheral effects as well as activity in the brain via the [[central nervous system]].
肥満症
GLP-1作動薬は、BMI が30を超えるか、またはBMIが27を超え、少なくとも1つの体重関連合併症を有する患者において、生活習慣介入(カロリー制限および運動)の上乗せ療法として推奨されている。セマグルチドなどの一部のGLP-1作動薬は、他の減量薬よりも効果が高いが、それでも体重減少を引き起こすという点では肥満手術 よりも効果が低い。GLP-1作動薬の体重減少効果は、末梢作用と中枢神経系 を介した脳内の活性の組み合わせから生じる。