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{{Short description|Substance that decreases activity of xanthine oxidase, an enzyme involved in purine metabolism}} ...emia]] and related medical conditions including [[gout]]. Xanthine oxidase inhibitors are being investigated for management of [[reperfusion injury]]. ...

{{Short description|Substance that decreases activity of xanthine oxidase, an enzyme involved in purine metabolism}} ...emia]] and related medical conditions including [[gout]]. Xanthine oxidase inhibitors are being investigated for management of [[reperfusion injury]]. ...

[[Image:Incretins and DPP 4 inhibitors.svg|thumb|300px|right|DPP-4阻害薬とGLP-1]] ...[[oral hypoglycemic/ja|経口血糖降下薬]]の一種であり、[[Enzyme inhibitors/ja|ブロック薬]]である。[[enzyme/ja|酵素]][[dipeptidyl peptidase-4/ja|ジペプチジルペプチダーゼ-4]]（DPP-4）を阻害する。これらは[[diabe ...

...ja|プリン代謝]]に関与する[[enzyme/ja|酵素]]である[[xanthine oxidase/ja|キサンチンオキシダーゼ]]の活性を[[enzyme inhibitor/ja|阻害薬]]する物質である。 [[human/ja|ヒト]]では、キサンチンオキシダーゼの阻害は[[uric acid/ja| {{Enzyme inhibition/ja}} ...

{{Short description|Enzyme blocker and diabetes treatment drug}} [[Image:Incretins and DPP 4 inhibitors.svg|thumb|300px|right|DPP-4 inhibitors and GLP-1]] ...

{{Short description|Enzyme blocker and diabetes treatment drug}} [[Image:Incretins and DPP 4 inhibitors.svg|thumb|300px|right|DPP-4 inhibitors and GLP-1]] ...

[[Image:Incretins and DPP 4 inhibitors.svg|thumb|350px|right|GLP-1 and DPP-4 inhibitors]] ...retion of GIP and GLP-1. Both GLP-1 and GIP are rapidly inactivated by the enzyme [[dipeptidyl peptidase-4]] (DPP-4) and are members of the glucagon peptide ...

[[Image:Incretins and DPP 4 inhibitors.svg|thumb|350px|right|GLP-1 and DPP-4 inhibitors]] ...retion of GIP and GLP-1. Both GLP-1 and GIP are rapidly inactivated by the enzyme [[dipeptidyl peptidase-4]] (DPP-4) and are members of the glucagon peptide ...

...チドに変換する。アンジオテンシンIはその後、主に[[lung/ja|肺]]の血管内皮細胞表面に存在する[[ngiotensin-converting enzyme/ja|アンジオテンシン変換酵素]]（ACE）によって[[angiotensin II/ja|アンジオテンシンII]]（オクタペプチド）に変換される。ア ...E阻害薬]]、[[angiotensin II receptor blocker/ja|アンジオテンシンⅡ受容体拮抗薬]]（ARB）、[[renin inhibitors/ja|レニン阻害薬]]など、血圧を改善するためにこのシステムのさまざまな段階を阻害する薬物がいくつかある。これらの薬物は、[[hypertension ...

...gene]]. DPP4 is related to [[FAP (gene)|FAP]], [[DPP8]], and [[DPP9]]. The enzyme was discovered in 1966 by Hopsu-Havu and Glenner, and as a result of variou The protein encoded by the ''DPP4'' gene is an [[enzyme]] expressed on the surface of most cell types and is associated with immune ...

...gene]]. DPP4 is related to [[FAP (gene)|FAP]], [[DPP8]], and [[DPP9]]. The enzyme was discovered in 1966 by Hopsu-Havu and Glenner, and as a result of variou The protein encoded by the ''DPP4'' gene is an [[enzyme]] expressed on the surface of most cell types and is associated with immune ...

''DPP4''遺伝子によってコードされるタンパク質は、ほとんどの細胞種の表面に発現する[[enzyme/ja|酵素]]であり、免疫調節、[[signal transduction/ja|シグナル伝達]]、および[[apoptosis/ja|アポトーシス] [[dipeptidyl peptidase-4 inhibitors/ja|ジペプチジルペプチダーゼ-4阻害薬]]と呼ばれる[[oral hypoglycemics/ja|経口血糖降下薬]]の一種は、この酵素の作用を阻害 ...

...質代謝に由来する廃棄物である。しかし、尿素は成長や生命維持に不可欠な窒素源として体内で利用される。尿素サイクルに最も関連する障害は遺伝的なもので、[[enzyme/ja|酵素]]または輸送体の欠陥によって尿酸塩の再吸収が阻害され、それに伴って有毒なアンモニア濃度が上昇する。 また、症状によっては医薬品が処方されることもある。腎臓病によく処方される医薬品には、[[angiotensin converting enzyme inhibitors/ja|アンジオテンシン変換酵素阻害薬]]（ACEI）や[[Angiotensin II receptor blocker/ja|アンジオテンシンII受 ...

...ted to [[angiotensin II]] (an octapeptide) by the [[angiotensin-converting enzyme]] (ACE) found on the surface of vascular endothelial cells, predominantly t ...ACE inhibitors]], [[angiotensin II receptor blocker]]s (ARBs), and [[renin inhibitors]] that interrupt different steps in this system to improve blood pressure. ...

...どがある。[[pregnancy/ja|妊娠中]]や[[breastfeeding/ja|授乳中]]の使用が安全かどうかは不明である。[[DPP-4 inhibitors/ja|ジペプチジルペプチダーゼ-4（DPP-4）阻害薬]]クラスに属し、膵臓による[[insulin/ja|インスリン]]の産生を増加させ、[[glu {{see also/ja|Dipeptidyl peptidase-4 inhibitors/ja}} ...

...ted to [[angiotensin II]] (an octapeptide) by the [[angiotensin-converting enzyme]] (ACE) found on the surface of vascular endothelial cells, predominantly t ...ACE inhibitors]], [[angiotensin II receptor blocker]]s (ARBs), and [[renin inhibitors]] that interrupt different steps in this system to improve blood pressure. ...

...[pregnancy]] or [[breastfeeding]] is safe is unclear. It is in the [[DPP-4 inhibitors|dipeptidyl peptidase-4 (DPP-4) inhibitor]] class and works by increasing th ...ncrease in pancreatic cancer has been reported in individuals taking DPP-4 inhibitors. ...

...[pregnancy]] or [[breastfeeding]] is safe is unclear. It is in the [[DPP-4 inhibitors|dipeptidyl peptidase-4 (DPP-4) inhibitor]] class and works by increasing th ...ncrease in pancreatic cancer has been reported in individuals taking DPP-4 inhibitors. ...

...h the ε-amino group of a specific lysine group of the [[aminotransferase]] enzyme. The α-amino group of the amino acid substrate displaces the ε-amino group ...]] when [[glucagon]] or [[epinephrine]] signals it to do so. However, this enzyme does not exploit the reactive aldehyde group, but instead utilizes the phos ...