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  • Discovery and development of dipeptidyl peptidase-4 inhibitors/en
    1. A deep [[lipophilic]] pocket combined with several exposed [[aromatic]] [[side chain]]s for achieving high affinity small molecule binding. ...e large [[hydrophobic]] [[amino acid]] groups bound to the [[azetidine]] [[nitrogen]] and are active below 100nM. ...
    32 KB (4,417 words) - 10:31, 12 March 2024
  • Discovery and development of dipeptidyl peptidase-4 inhibitors
    1. A deep [[lipophilic]] pocket combined with several exposed [[aromatic]] [[side chain]]s for achieving high affinity small molecule binding. ...e large [[hydrophobic]] [[amino acid]] groups bound to the [[azetidine]] [[nitrogen]] and are active below 100nM. ...
    33 KB (4,561 words) - 10:30, 12 March 2024
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