II型コラーゲン
Type II collagen/ja
| コラーゲン、II型、α1（一次性変形性関節症、脊椎骨端形成不全、先天性） | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | COL2A1 | ||||||
| Alt. symbols | SEDC | ||||||
| NCBI gene | 1280 | ||||||
| HGNC | 2200 | ||||||
| OMIM | 120140 | ||||||
| RefSeq | NM_001844 | ||||||
| UniProt | P02458 | ||||||
| Other data | |||||||
| Locus | Chr. 12 q13.11-q13.2 | ||||||
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II型コラーゲンは関節表面の関節軟骨を含むヒアリン軟骨の基礎である。コラーゲンはII型コラーゲンα1鎖のホモ三量体によって形成される。
軟骨に含まれる全タンパク質の50％、関節軟骨のコラーゲンの85～90％を占める。
Type II collagen is organised into fibrils. This fibrillar network of collagen allows the cartilage to entrap the proteoglycan aggregate, as well as providing tensile strength to the tissue. Oral administration of native type II collagen induces oral tolerance to pathological immune responses and may be useful in arthritis.
Supplements containing Type II collagen have been reported to have positive impact on skin health. A review and analysis of 19 studies found that participants who used collagen supplements saw an improvement in the firmness, suppleness, and moisture content of the skin, with wrinkles appearing less noticeable. There is still a need for large, high-quality studies to determine the scientific impact of Type II collagen supplements on skin health.
External links
- Collagen+type+II at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
 | この記事は、クリエイティブ・コモンズ・表示・継承ライセンス3.0のもとで公表されたウィキペディアの項目Type II collagen/ja(21 January 2024編集記事参照)を素材として二次利用しています。 Lua error in Module:Itemnumber at line 91: attempt to concatenate local 'qid' (a nil value). |