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Febuxostat/22/en
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v
t
e
Drugs used for
gout
(
M04
)
Uricosurics
primary
Probenecid
Sulfinpyrazone
Benzbromarone
Isobromindione
secondary
Amlodipine
Atorvastatin
Fenofibrate
Guaifenesin
Lesinurad
‡
Losartan
Xanthine oxidase inhibitors
purine analogues
Allopurinol
#
Oxypurinol
Tisopurine
other
Febuxostat
Inositols
(
Phytic acid
Myo-inositol
)
Topiroxostat
Mitotic inhibitors
Colchicine
Other
Cinchophen
NSAIDs
except
aspirin
Sevelamer
Urate oxidase
(
Rasburicase
Pegloticase
)
#
WHO-EM
‡
Withdrawn
from market
Clinical trials
:
†
Phase III
§
Never to phase III
v
t
e
Purine receptor
modulators
Receptor
(
ligands
)
P0
(
adenine
)
Agonists:
8-Aminoadenine
Adenine
P1
(
adenosine
)
Agonists:
2-(1-Hexynyl)-
N
-methyladenosine
2-Cl-IB-MECA
2'-MeCCPA
4'-O-β-D-Glucosyl-9-O-(6''-deoxysaccharosyl)olivil
5'-
N
-ethylcarboxamidoadenosine
Adenosine
ADP
AMP
Apadenoson
ATL-146e
ATP
BAY 60–6583
Binodenoson
Capadenoson
CCPA
CGS-21680
CP-532,903
Evodenoson
GR 79236
LUF-5835
LUF-5845
N
6
-Cyclopentyladenosine
Namodenoson
Neladenoson dalanate
Piclidenoson
Regadenoson
SDZ WAG 994
Selodenoson
Sonedenoson
Tecadenoson
UK-432,097
Antagonists:
7-Methylxanthine
8-Chlorotheophylline
8-Phenyl-1,3-dipropylxanthine
8-Phenyltheophylline
Acefylline
Aminophylline
ATL-444
Bamifylline
Cafedrine
Caffeine
Caffeine citrate
Cartazolate
CGH-2466
CGS-15943
Choline theophyllinate
Ciforadenant
CPX
CVT-6883
Dimethazan
DMPX
DPCPX
Dyphylline
Enprofylline
Etazolate
Fenethylline
IBMX
Isovaleric acid
Istradefylline
KF-26777
MRE3008F20
MRS-1220
MRS-1334
MRS-1706
MRS-1754
MRS-3777
Paraxanthine
Pentoxifylline
Preladenant
Propentofylline
Proxyphylline
PSB-10
PSB-11
PSB-36
PSB-603
PSB-788
PSB-1115
Reversine
Rolofylline
SCH-442,416
SCH-58261
Theacrine
Theobromine
Theodrenaline
Theophylline
Tozadenant
Tracazolate
VUF-5574
ZM-241,385
P2
(
nucleotide
)
P2X
(
ATP
Tooltip Adenosine triphosphate
)
Agonists:
2-Me-SATP
α,β-Me-ATP
Adenosine
ADP
AMP
Ap4A
Ap5A
ATP
ATPγS
BzATP
Cibacron blue
CTP
D-β,γ-Me-ATP
GTP
HT-AMP
Ivermectin
L-β,γ-Me-ATP
MRS-2219
PAPET-ATP
UTP
Zinc
Antagonists:
5-BDBD
A-317491
A-438079
A-740003
A-804598
A-839977
AF-353
AZ-10606120
AZ-11645373
BBG
Calcium
Calmidazolium
Chelerythrine
Copper
Emodin
(
Rheum officinale
)
Evans blue
Gefapixant
GW-791343
HMA
Ip5I
isoPPADS
JNJ-47965567
KN-04
KN-62
Magnesium
MRS-2159
NF-023
NF-110
NF-157
NF-279
NF-449
Opiranserin (VVZ-149)
Oxidized-ATP
Phenol Red
Phenolphthalein
PPADS
PPNDS
PSB-12062
Puerarin
(
Radix puerariae
)
Purotoxin 1
RB-2
Ro 0437626
Ro 51
RO-3
Sodium ferulate
(
Angelica sinensis
,
Ligusticum wallichii
)
Suramin
TC-P 262
Tetramethylpyrazine (ligustrazine)
(
Ligusticum wallichii
)
TNP-ATP
Zinc
P2Y
Agonists:
2-Me-SADP
2-Me-SATP
2-Thio-UTP
5-Br-UDP
5-OMe-UDP
α,β-Me-ATP
Adenosine
ADP
ADPβS
Ap3A
AR-C 67085MX
ATP
ATPγS
CTP
dATP
Denufosol
Diquafosol
IDP
ITP
INS-365
INS-37217
MRS-2365
MRS-2690
MRS-2693
MRS-2768
MRS-2957
MRS-4062
NF-546
PAPET-ATP
PSB-0474
PSB-1114
UDP
UDPβS
UDP-galactose
UDP-glucose
UDP-N-acetylglucosamine
Up3U
UTP
UTPγS
Antagonists:
2-Me-SAMP
A3P5PS
AMPαS
Ap4A
AR-C 66096
AR-C 67085MX
AR-C 69931MX
AR-C 118925XX
ATP
BzATP
C1330-7
Cangrelor
Clopidogrel
Elinogrel
Ip5I
MRS-2179
MRS-2211
MRS-2279
MRS-2395
MRS-2500
MRS-2578
NF-157
NF-340
PIT
PPADS
Prasugrel
PSB-0739
RB-2
Regrelor
Suramin
Ticagrelor
Ticlopidine
UDP
Transporter
(
blockers
)
CNTs
Tooltip Concentrative nucleoside transporters
6-Hydroxy-7-methoxyflavone
Adenosine
dMeThPmR
Estradiol
KGO-2142
KGO-2173
MeThPmR
Phloridzin
Progesterone
ENTs
Tooltip Equilibrative nucleoside transporters
Barbiturates
Benzodiazepines
Cilostazol
Dilazep
Dipyridamole
Estradiol
Ethanol
Hexobendine
NBMPR
Pentoxifylline
Progesterone
Propentofylline
PMAT
Tooltip Plasma membrane monoamine transporter
Decynium-22
Enzyme
(
inhibitors
)
XO
Tooltip Xanthine oxidase
Allopurinol
Amflutizole
Benzbromarone
Caffeic acid
Cinnamaldehyde
Cinnamomum osmophloeum
Febuxostat
Myo-inositol
Kaempferol
Myricetin
Niraxostat
Oxipurinol
Phytic acid
Pistacia integerrima
Propolis
Quercetin
Tisopurine
Topiroxostat
Others
Aminopterin
Azathioprine
Methotrexate
Mycophenolic acid
Pemetrexed
Pralatrexate
Many others
Others
Precursors:
Adenine
Adenosine
AMP
ADP
ATP
Cytosine
Cytidine
CMP
CDP
CTP
Guanine
Guanosine
GMP
GDP
GTP
Hypoxanthine
Inosine
IMP
IDP
ITP
Ribose
Uracil
Uridine
UMP
UDP
UTP
Others:
Chrysophanol
(
rhubarb
)
See also:
Receptor/signaling modulators
Portal
:
Medicine