Translations:Sporulation in Bacillus subtilis/6/en
In the table below, the term 'Activators' refers to genes/proteins that ultimately result in initiation of sporulation and 'Repressors' refers to the ones that inhibit this initiation of sporulation.
| Activators | Regulation | Repressors | Regulation |
|---|---|---|---|
| KinA | Transfers phosphate to the Spo0F | Sda | Blocks autophosphorylation of KinA |
| KinB | Transfers phosphate to the Spo0F | KipI | Blocks autophosphorylation of KinA |
| Spo0A | Activates several key sporulation-specific genes | Spo0A | Negatively controls transcription of abrB |
| Spo0H (σH) | Activates phrE gene | ComA | Activates competence |
| Spo0B | Phosphotransferase initiation | SinR | Negative regulation of kinB |
| Spo0F | Phosphotransferase initiation | RapA, RapB, RapE, and RapH | Dephosphorylation of Spo0F~P |
| ComA | Activates phrA | Spo0E, YisI, and YnzD | Dephosphorylation of Spo0A~P |
| SinI | Antagonist of SinR | GTP-bound CodY | Inhibits rapA-phrA |
| KipA | Inhibits kipI gene | AbrB | Encodes a repressor of spo0H |
| PhrA | Suppresses dephosphorylation activity of RapA | Hpr | Overexpression inhibits sporulation |
| PhrE | Inhibits RapE | DnaA | Over expression of Sda |
| PhrH | Inhibits RapH |