Tacalcitol

Tacalcitol
Clinical data
Other names	(1α,24R)-1,24-Dihydroxyvitamin D3
AHFS/Drugs.com	International Drug Names
Routes of; administration	Topical
ATC code	D05AX04 (WHO) ;
Identifiers
	IUPAC name (1S,3R,5Z,7E,24R)-9,10-secocholesta-5,7,10-triene-1,3,24-triol;
CAS Number	57333-96-7 ;
PubChem CID	5283734;
IUPHAR/BPS	2780;
ChemSpider	4446823 ;
UNII	C2W72OJ5ZU;
ChEBI	CHEBI:32176;
ChEMBL	ChEMBL340361 ;
Chemical and physical data
Formula	C27H44O3
Molar mass	416.646 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O[C@@H]1CC(\C(=C)[C@@H](O)C1)=C\C=C2/CCC[C@]3([C@H]2CC[C@@H]3[C@H](C)CC[C@@H](O)C(C)C)C;
	InChI InChI=1S/C27H44O3/c1-17(2)25(29)13-8-18(3)23-11-12-24-20(7-6-14-27(23,24)5)9-10-21-15-22(28)16-26(30)19(21)4/h9-10,17-18,22-26,28-30H,4,6-8,11-16H2,1-3,5H3/b20-9+,21-10-/t18-,22-,23-,24+,25-,26+,27-/m1/s1 ; Key:BJYLYJCXYAMOFT-RSFVBTMBSA-N ;
	(what is this?) (verify)

Tacalcitol (1,24-dihydroxyvitamin D₃) is a synthetic vitamin D₃ analog. Tacalcitol is marketed under several names, including Curatoderm and Bonalfa.

It is on the World Health Organization's List of Essential Medicines.

Mechanism

Tacalcitol reduces excessive cell turnover in the epidermis by interacting with vitamin D receptors on keratinocytes.

Uses

It is usually prescribed by a general practitioner or dermatologist for the treatment of psoriasis, chronic chapped lips and other severe dry skin conditions because of its ability to reduce excessive skin cell turnover.^[1] It is available as an ointment or lotion.

It has also been used for vitiligo and Hailey-Hailey disease.

この記事は、クリエイティブ・コモンズ・表示・継承ライセンス3.0のもとで公表されたウィキペディアの項目Tacalcitol(11 February 2024編集記事参照)を素材として二次利用しています。
Item:Q22024

↑ Cite error: Invalid <ref> tag; no text was provided for refs named pmid9257082

[pmid9257082-1] Cite error: Invalid <ref> tag; no text was provided for refs named pmid9257082

[1]

Clinical data

Other names	(1α,24R)-1,24-Dihydroxyvitamin D₃
AHFS/Drugs.com	International Drug Names
Routes of administration	Topical
ATC code	D05AX04 (WHO)
Identifiers
IUPAC name (1S,3R,5Z,7E,24R)-9,10-secocholesta-5,7,10-triene-1,3,24-triol
CAS Number	57333-96-7^Y
PubChem CID	5283734
IUPHAR/BPS	2780
ChemSpider	4446823^N
UNII	C2W72OJ5ZU
ChEBI	CHEBI:32176
ChEMBL	ChEMBL340361^N
Chemical and physical data
Formula	C₂₇H₄₄O₃
Molar mass	416.646 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O[C@@H]1CC(\C(=C)[C@@H](O)C1)=C\C=C2/CCC[C@]3([C@H]2CC[C@@H]3[C@H](C)CC[C@@H](O)C(C)C)C
InChI InChI=1S/C27H44O3/c1-17(2)25(29)13-8-18(3)23-11-12-24-20(7-6-14-27(23,24)5)9-10-21-15-22(28)16-26(30)19(21)4/h9-10,17-18,22-26,28-30H,4,6-8,11-16H2,1-3,5H3/b20-9+,21-10-/t18-,22-,23-,24+,25-,26+,27-/m1/s1^N Key:BJYLYJCXYAMOFT-RSFVBTMBSA-N^N
^NY (what is this?) (verify)