| Family |
Function |
Members |
Genes |
Pseudogenes
|
| CYP1 |
drug and steroid (especially estrogen) metabolism, benzo[a]pyrene toxification (forming (+)-benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide) |
3 subfamilies, 3 genes, 1 pseudogene |
CYP1A1, CYP1A2, CYP1B1 |
CYP1D1P
|
| CYP2 |
drug and steroid metabolism |
13 subfamilies, 16 genes, 16 pseudogenes |
CYP2A6, CYP2A7, CYP2A13, CYP2B6, CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP2R1, CYP2S1, CYP2U1, CYP2W1 |
Too many to list
|
| CYP3 |
drug and steroid (including testosterone) metabolism |
1 subfamily, 4 genes, 4 pseudogenes |
CYP3A4, CYP3A5, CYP3A7, CYP3A43 |
CYP3A51P, CYP3A52P, CYP3A54P, CYP3A137P
|
| CYP4 |
arachidonic acid or fatty acid metabolism |
6 subfamilies, 12 genes, 10 pseudogenes |
CYP4A11, CYP4A22, CYP4B1, CYP4F2, CYP4F3, CYP4F8, CYP4F11, CYP4F12, CYP4F22, CYP4V2, CYP4X1, CYP4Z1 |
Too many to list
|
| CYP5 |
thromboxane A2 synthase |
1 subfamily, 1 gene |
CYP5A1 |
|
| CYP7 |
bile acid biosynthesis 7-alpha hydroxylase of steroid nucleus |
2 subfamilies, 2 genes |
CYP7A1, CYP7B1 |
|
| CYP8 |
varied |
2 subfamilies, 2 genes |
CYP8A1 (prostacyclin synthase), CYP8B1 (bile acid biosynthesis) |
|
| CYP11 |
steroid biosynthesis |
2 subfamilies, 3 genes |
CYP11A1, CYP11B1, CYP11B2 |
|
| CYP17 |
steroid biosynthesis, 17-alpha hydroxylase |
1 subfamily, 1 gene |
CYP17A1 |
|
| CYP19 |
steroid biosynthesis: aromatase synthesizes estrogen |
1 subfamily, 1 gene |
CYP19A1 |
|
| CYP20 |
unknown function |
1 subfamily, 1 gene |
CYP20A1 |
|
| CYP21 |
steroid biosynthesis |
1 subfamilies, 1 gene, 1 pseudogene |
CYP21A2 |
CYP21A1P
|
| CYP24 |
vitamin D degradation |
1 subfamily, 1 gene |
CYP24A1 |
|
| CYP26 |
retinoic acid hydroxylase |
3 subfamilies, 3 genes |
CYP26A1, CYP26B1, CYP26C1 |
|
| CYP27 |
varied |
3 subfamilies, 3 genes |
CYP27A1 (bile acid biosynthesis), CYP27B1 (vitamin D3 1-alpha hydroxylase, activates vitamin D3), CYP27C1 (vitamin A1 to A2) |
|
| CYP39 |
7-alpha hydroxylation of 24-hydroxycholesterol |
1 subfamily, 1 gene |
CYP39A1 |
|
| CYP46 |
cholesterol 24-hydroxylase |
1 subfamily, 1 gene, 1 pseudogene |
CYP46A1 |
CYP46A4P
|
| CYP51 |
cholesterol biosynthesis |
1 subfamily, 1 gene, 3 pseudogenes |
CYP51A1 (lanosterol 14-alpha demethylase) |
CYP51P1, CYP51P2, CYP51P3
|