Translations:Vitamin B12/72/en

Cellular reprogramming

Vitamin B₁₂ through its involvement in one-carbon metabolism plays a key role in cellular reprogramming and tissue regeneration and epigenetic regulation. Cellular reprogramming is the process by which somatic cells can be converted to a pluripotent state. Vitamin B₁₂ levels affect the histone modification H3K36me3, which suppresses illegitimate transcription outside of gene promoters. Mice undergoing in vivo reprogramming were found to become depleted in B₁₂ and show signs of methionine starvation while supplementing reprogramming mice and cells with B₁₂ increased reprogramming efficiency, indicating a cell-intrinsic effect.