Translations:Sporulation in Bacillus subtilis/5/en
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Control points
Two transcriptional regulators, σH and Spo0A, play key roles in initiation of sporulation. Several additional proteins participate, mainly by controlling the accumulated concentration of Spo0A~P. Spo0A lies at the end of a series of inter-protein phosphotransfer reactions, Kin–Spo0F–Spo0B–Spo0A, termed as a ‘phosphorelay’. The regulation of these various factors controlling the accumulated concentration of Spo0A~P, and their interactions are described in detail in Figure2:
