Translations:Folate/24/en

Neurological disorders

Conversion of homocysteine to methionine requires folate and vitamin B₁₂. Elevated plasma homocysteine and low folate are associated with cognitive impairment, dementia and Alzheimer's disease. Supplementing the diet with folic acid and vitamin B₁₂ lowers plasma homocysteine. However, several reviews reported that supplementation with folic acid alone or in combination with other B vitamins did not prevent development of cognitive impairment nor slow cognitive decline.