Translations:Calcifediol/1/en

Calcifediol/1/en

Names
Preferred IUPAC name (1S,3Z)-3-[(2E)-2-{(1R,3aS,7aR)-1-[(2R)-6-Hydroxy-6-methylheptan-2-yl]-7a-methyloctahydro-4H-inden-4-ylidene}ethylidene]-4-methylidenecyclohexan-1-ol
Other names 25-Hydroxyvitamin D3 25-Hydroxycholecalciferol Calcidiol
Identifiers
CAS Number	19356-17-3 Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:17933 N
ChEMBL	ChEMBL1222 Y
ChemSpider	4446820 N
DrugBank	DB00146 Y
IUPHAR/BPS	6921
KEGG	C01561
MeSH	Calcifediol
PubChem CID	5283731
UNII	T0WXW8F54E Y
InChI InChI=1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1 N Key: JWUBBDSIWDLEOM-DTOXIADCSA-N N InChI=1/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1 Key: JWUBBDSIWDLEOM-DTOXIADCBI
SMILES O[C@@H]1CC(\C(=C)CC1)=C\C=C2/CCC[C@]3([C@H]2CC[C@@H]3[C@H](C)CCCC(O)(C)C)C
Properties
Chemical formula	C27H44O2
Molar mass	400.64 g/mol
Pharmacology
ATC code	H05BX05 (WHO)

Calcifediol, also known as calcidiol, 25-hydroxycholecalciferol, or 25-hydroxyvitamin D₃ (abbreviated 25(OH)D₃), is a form of vitamin D produced in the liver by hydroxylation of vitamin D₃ (cholecalciferol) by the enzyme vitamin D 25-hydroxylase. Calcifediol can be further hydroxylated by the enzyme 25(OH)D-1α-hydroxylase, primarily in the kidney, to form calcitriol (1,25-(OH)₂D₃), which is the active hormonal form of vitamin D.