Translations:Angiotensin II receptor blocker/21/en

Mechanism of action

These substances are AT₁-receptor antagonists; that is, they block the activation of angiotensin II AT₁ receptors. AT₁ receptors are found in smooth muscle cells of vessels, cortical cells of the adrenal gland, and adrenergic nerve synapses. Blockage of AT₁ receptors directly causes vasodilation, reduces secretion of vasopressin, and reduces production and secretion of aldosterone, among other actions. The combined effect reduces blood pressure.