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Found 2 translations.
| Name | Current message text |
|---|---|
| h English (en) | After the IF/B<sub>12</sub> complex binds to cubam the complex is disassociated and the free vitamin is transported into the [[portal circulation]]. The vitamin is then transferred to TC2, which serves as the circulating plasma transporter, Hereditary defects in production of TC2 and its receptor may produce functional deficiencies in B<sub>12</sub> and infantile [[megaloblastic anemia]], and abnormal B<sub>12</sub> related biochemistry, even in some cases with normal blood B<sub>12</sub> levels. For the vitamin to serve inside cells, the TC2-B<sub>12</sub> complex must bind to a cell receptor protein and be [[endocytosis|endocytosed]]. TC2 is degraded within a [[lysosome]], and free B<sub>12</sub> is released into the cytoplasm, where it is transformed into the bioactive coenzyme by cellular enzymes. |
| h Japanese (ja) | IF/B<sub>12</sub>複合体がキュバムに結合した後、複合体は解離し、遊離ビタミンは[[portal circulation/ja|門脈循環]]に輸送される。TC2およびそのレセプターの遺伝的産生不全は、B<sub>12</sub>の機能的欠乏や小児[[megaloblastic anemia/ja|巨赤芽球性貧血]]、血中B<sub>12</sub>濃度が正常であってもB<sub>12</sub>関連生化学の異常を引き起こす。ビタミンが細胞内で機能するためには、TC2-B<sub>12</sub>複合体は細胞受容体タンパク質と結合し、[[endocytosisエンドサイトーシス]]されなければならない。TC2は[[lysosome/ja|リソソーム]]内で分解され、遊離したB<sub>12</sub>は細胞質に放出され、そこで細胞酵素によって生理活性補酵素に変換される。 |