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Found 2 translations.
| Name | Current message text |
|---|---|
| h English (en) | Sulfonylureas bind to and close [[ATP-sensitive potassium channel|ATP-sensitive K<sup>+</sup>]] (K<sub>ATP</sub>) channels on the cell membrane of pancreatic [[beta cell]]s, which depolarizes the cell by preventing potassium from exiting. This [[depolarization]] opens voltage-gated [[calcium|Ca]]<sup>2+</sup> channels. The rise in intracellular calcium leads to increased fusion of [[insulin]] granules with the cell membrane, and therefore increased [[Insulin#Synthesis|secretion]] of mature insulin. |
| h Japanese (ja) | スルホニル尿素は、膵[[beta cell/ja|β細胞]]の細胞膜上の[[ATP-sensitive potassium channel/ja|ATP感受性K<sup>+</sup>]](K<sub>ATP</sub>)チャネルに結合して閉じ、カリウムが外に出るのを妨げることによって細胞を脱分極させる。この[[depolarization/ja|脱分極]]は、電位依存性[[calcium/ja|Ca]]<sup>2+</sup>チャネルを開く。細胞内カルシウムの上昇は、[[insulin/ja|インスリン]]顆粒と細胞膜の融合を増加させ、成熟インスリンの[[Insulin/ja#Synthesis|分泌]]を増加させる。 |