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Found 2 translations.
| Name | Current message text |
|---|---|
| h English (en) | A meta-analysis including 13 cardiovascular outcome trials found that SGLT-2 inhibitors reduce the risk for three-point [[Major adverse cardiovascular events|MACE]], especially in subjects with an [[estimated glomerular filtration rate]] (eGFR) below 60 ml/min, whereas [[Glucagon-like peptide-1 receptor agonist|GLP-1 receptor agonists]] were more beneficial in persons with higher eGFR. Likewise, the risk reduction due to SGLT-2 inhibitors was larger in populations with a higher proportion of [[albuminuria]], but this relationship was not observed for GLP-1 receptor agonists. This suggests a differential use of the two substance classes in patients with preserved and reduced renal function or with and without [[diabetic nephropathy]], respectively. |
| h Japanese (ja) | 13の心血管アウトカム試験を含むメタアナリシスによると、SGLT-2阻害薬は、特に[[estimated glomerular filtration rate/ja|推算糸球体濾過量]]（eGFR）が60ml/分未満の被験者において、3点[[Major adverse cardiovascular events/ja|MACE]]のリスクを低下させるが、[[Glucagon-like peptide-1 receptor agonist/ja|GLP-1受容体作動薬]]はeGFRが高い人ほど有益であった。同様に、SGLT-2阻害薬によるリスク低減は、[[albuminuria/ja|アルブミン尿]]の割合が高い集団でより大きかったが、GLP-1受容体作動薬ではこの関係は観察されなかった。このことは，腎機能が保たれている患者と低下している患者，あるいは[[diabetic nephropathy/ja|糖尿病性腎症]]のある患者とない患者で，2つの物質クラスがそれぞれ異なって使用されることを示唆している。 |