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Found 2 translations.
| Name | Current message text |
|---|---|
| h English (en) | {| class="wikitable" |+ TABLE 2: PHARMACOKINETIC PARAMETERS OF VARIOUS SGLT-2 INHIBITORS |- ! Name of drug !! Bioavailability !! Protein binding !! tmax (hours) !! t1/2 (hours) !! Cmax !! SGLT2 selectivity over SGLT1 |- | [[Canagliflozin]] || 65% (300 mg dose) || 99% || 1–2 || 10.6 (100 mg dose); 13.1 (300 mg dose) || 1096 ng/mL (100 mg dose); 3480 ng/mL (300 mg dose) || 250 fold |- | [[Dapagliflozin]] || 78% || 91% || 1–1.5 || 12.9 || 79.6 ng/mL (5 mg dose); 165.0 ng/mL (10 mg dose) || 1200 fold |- | [[Empagliflozin]] || 90–97% (mice); 89% (dogs); 31% (rats) || 86.20% || 1.5 || 13.2 (10 mg dose); 13.3h (25 mg dose) || 259nmol/L (10 mg dose); 687nmol/L (25 mg dose) || 2500 fold |- | [[Ertugliflozin]] || 70-90% || 95% || 0.5-1.5 || 11-17 ||268 ng/mL (15 mg dose) || 2000 fold |- | [[Ipragliflozin]] (50 mg) || 90% || 96.30% || 1 || 15–16 (50 mg dose) || 975 ng/mL || 360 fold |- | [[Luseogliflozin]] || 35.3% (male rats); 58.2% (female rats); 92.7% (male dogs) || 96.0–96.3% || 0.625±0.354 || 9.24±0.928 || 119±27.0 ng/mL || 1650 fold |- |
| h Japanese (ja) | {| class="wikitable" |+ 表2: 様々なSGLT-2阻害剤の薬物動態パラメータ |- ! 薬物名 !! 生物学的利用能 !! タンパク質結合 !! tmax（時間） !! t1/2 (hours) !! Cmax !! SGLT1に対するSGLT2選択性 |- | [[Canagliflozin/ja]] || 65% (300 mg dose) || 99% || 1–2 || 10.6 (100 mg dose); 13.1 (300 mg dose) || 1096 ng/mL (100 mg dose); 3480 ng/mL (300 mg dose) || 250 fold |- | [[Dapagliflozin/ja]] || 78% || 91% || 1–1.5 || 12.9 || 79.6 ng/mL (5 mg dose); 165.0 ng/mL (10 mg dose) || 1200 fold |- | [[Empagliflozin/ja]] || 90–97% (mice); 89% (dogs); 31% (rats) || 86.20% || 1.5 || 13.2 (10 mg dose); 13.3h (25 mg dose) || 259nmol/L (10 mg dose); 687nmol/L (25 mg dose) || 2500 fold |- | [[Ertugliflozin/ja]] || 70-90% || 95% || 0.5-1.5 || 11-17 ||268 ng/mL (15 mg dose) || 2000 fold |- | [[Ipragliflozin/ja]] (50 mg) || 90% || 96.30% || 1 || 15–16 (50 mg dose) || 975 ng/mL || 360 fold |- | [[Luseogliflozin/ja]] || 35.3% (male rats); 58.2% (female rats); 92.7% (male dogs) || 96.0–96.3% || 0.625±0.354 || 9.24±0.928 || 119±27.0 ng/mL || 1650 fold |- |