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 h English (en)=== Neurodegenerative diseases ===
People who have neurodegenerative diseases like [[Huntington's disease]], [[dementia]], [[Parkinson's disease]], and [[amyotrophic lateral sclerosis]] (ALS), also often show symptoms of protein toxicity. Cellular deficits and genetic mutations caused by these neurodegenerative diseases can pathologically alter gene transcription, negatively affecting protein metabolism.
 h Japanese (ja)=== 神経変性疾患 ===
[[Huntington's disease/ja|ハンチントン病]]、[[dementia/ja|認知症]]、[[Parkinson's disease/ja|パーキンソン病]]、[[amyotrophic lateral sclerosis/ja|筋萎縮性側索硬化症]](ALS)のような神経変性疾患に罹患している人も、しばしばタンパク質毒性の症状を示す。これらの神経変性疾患によって引き起こされる細胞欠損や遺伝子変異は、遺伝子の転写を病的に変化させ、タンパク質代謝に悪影響を及ぼす。