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NameCurrent message text
 h English (en)In [[animal model]]s and ''[[in vitro]]'', niacin produces marked anti-inflammatory effects in a variety of tissues – including the brain, gastrointestinal tract, skin, and [[Inflammation#Vascular component|vascular tissue]] – through the activation of [[hydroxycarboxylic acid receptor 2]] (HCA2), also known as niacin receptor 1 (NIACR1). Unlike niacin, nicotinamide does not activate NIACR1; however, both niacin and nicotinamide activate the [[G protein-coupled estrogen receptor]] (GPER) ''in vitro''.
 h Japanese (ja)[[animal model/ja|動物モデル]]および''[[in vitro/ja|試験管内]]''において、ナイアシンは、ナイアシン受容体1(NIACR1)としても知られる[[hydroxycarboxylic acid receptor 2/ja|ヒドロキシカルボン酸受容体2]](HCA2)の活性化を通じて、脳、消化管、皮膚、[[Inflammation/ja#Vascular component|血管組織]]などの様々な組織 において顕著な抗炎症作用をもたらす。ナイアシンとは異なり、ニコチンアミドはNIACR1を活性化しない。しかし、ナイアシンもニコチンアミドも試験管内で[[G protein-coupled estrogen receptor/ja|Gタンパク質共役型エストロゲン受容体]](GPER)を活性化する。