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Found 2 translations.
| Name | Current message text |
|---|---|
| h English (en) | The acute adverse effects of high-dose niacin therapy ({{nowrap|1–3 grams per day}}) – which is commonly used in the treatment of [[hyperlipidemia]]s – can further include [[hypotension]], fatigue, [[glucose intolerance]] and [[insulin resistance]], heartburn, blurred or impaired vision, and [[macular edema]]. With long-term use, the adverse effects of high-dose niacin therapy (750 mg per day) also include [[liver failure]] (associated with fatigue, nausea, and [[loss of appetite]]), [[hepatitis]], and [[acute liver failure]]; these hepatotoxic effects of niacin occur more often when extended-release [[dosage form]]s are used. The long-term use of niacin at greater than or equal to 2 grams per day also significantly increases the [[risk ratio|risk]] of [[cerebral hemorrhage]], [[ischemic stroke]], [[gastrointestinal ulcer]]ation and [[gastrointestinal bleeding|bleeding]], [[diabetes]], [[dyspepsia]], and diarrhea. |
| h Japanese (ja) | 高用量ナイアシン療法（{{nowrap|1-3 g/日}}）の急性有害作用には、さらに[[hyperlipidemia/ja|高脂血症]]の治療に一般的に用いられる[[hypotension/ja|低血圧]]、疲労、[[glucose intolerance/ja|耐糖能異常]]および[[insuline registance/ja|インスリン抵抗性]]、胸やけ、かすみ目または視力障害、および[[macular edema/ja|黄斑浮腫]]が含まれる。長期使用では、高用量ナイアシン療法（750 mg/日）の有害作用には、[[liver failure/ja|肝不全]]（疲労、吐き気、および[[loss of appetite/ja|食欲不振]]を伴う）、[[hepatitis/ja|肝炎]]、および[[acute liver failure/ja|急性肝不全]]も含まれる；ナイアシンのこれらの肝毒性作用は、徐放性[[dosage form/ja|剤形]]が使用される場合に、より頻繁に起こる。1日2グラム以上のナイアシンの長期使用は、[[cerebral hemorrhage/ja|脳出血]]、[[ischemic stroke/ja|虚血性脳卒中]]、[[gastrointestinal ulcer/ja|消化管潰瘍]]および[[gastrointestinal bleeding/ja|消化管出血]]、[[diabetes/ja|糖尿病]]、[[hyspepsia/ja|消化不良]]、および下痢の[[risk ratio/ja|リスク]]を有意に増加させる。 |