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 h English (en)===Application of the scientific method and Modern metabolic theories===
The history of the scientific study of metabolism spans several centuries and has moved from examining whole animals in early studies, to examining individual metabolic reactions in modern biochemistry. The first controlled [[experiment]]s in human metabolism were published by [[Santorio Santorio]] in 1614 in his book ''Ars de statica medicina''. He described how he weighed himself before and after eating, [[sleeping|sleep]], working, sex, fasting, drinking, and excreting. He found that most of the food he took in was lost through what he called "[[insensible perspiration]]".
 h Japanese (ja)===科学的手法の応用と現代の代謝理論=== 
代謝の科学的研究の歴史は数世紀にわたっており、初期の研究では動物全体を調べることから、現代の生化学では個々の代謝反応を調べるようになった。ヒトの代謝における最初の対照[[experiment/ja|実験]]は、1614年に[[:en:Santorio Santorio|Santorio Santorio]]が著書''Ars de statica medicina''の中で発表した。彼は食事、[[sleeping/ja|睡眠]]、仕事、セックス、絶食、飲酒、排泄の前後に体重を測定した方法を記述した。彼は、摂取した食物のほとんどが"[[insensible perspiration/ja|不感蒸泄性発汗]]"と呼ばれるもので失われることを発見した。