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Found 2 translations.

Name	Current message text
^h English (en)	==Modifications== Before biosynthetic human [[Recombinant DNA\|recombinant]] analogues were available, porcine insulin was chemically converted into human insulin. Chemical modifications of the amino acid side chains at the [[N-terminus]] and/or the [[C-terminus]] were made in order to alter the [[ADME]] characteristics of the analogue. Semisynthetic insulins were clinically used for some time based on chemical modification of animal insulins, for example [[Novo Nordisk]] enzymatically converted porcine insulin into semisynthetic 'human' insulin by removing the single amino acid that varies from the human variety, and chemically adding the human amino acid.
^h Japanese (ja)	==修正== 生合成ヒト[[Recombinant DNA/ja\|組換え]]類似体が利用可能になる前は、ブタインスリンは化学的にヒトインスリンに変換された。アナログの[[ADME/ja\|ADME]]特性を変えるために、[[N-terminus/ja\|N末端]]および/または[[C-terminus/ja\|C末端]]のアミノ酸側鎖の化学修飾が行われた。例えば、[[Novo Nordisk]]はブタインスリンを酵素的に半合成「ヒト」インスリンに変換し、ヒトとは異なる1つのアミノ酸を除去し、ヒトアミノ酸を化学的に付加した。