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 h English (en)In those with a history of diabetes treated with [[Insulin (medication)|insulin]], [[Meglitinide|glinides]], or [[sulfonylurea]], who demonstrate Whipple's triad, it is reasonable to assume the cause of hypoglycemia is due to insulin, glinides, or sulfonylurea use. In those without a history of diabetes with hypoglycemia, further diagnostic testing is necessary to identify the cause. Testing, during an episode of hypoglycemia, should include the following:
* [[Blood sugar level|Plasma glucose]] level, not [[Point of care|point-of-care]] measurement
* Insulin level
* [[C-peptide]] level
* [[Proinsulin]] level
* [[Beta-Hydroxybutyric acid|Beta-hydroxybutyrate]] level
* Oral hypoglycemic agent screen
* Response of blood glucose level to glucagon
* Insulin [[Antibody|antibodies]]
If necessary, a diagnostic hypoglycemic episode can be produced in an inpatient or outpatient setting. This is called a diagnostic [[Fasting|fast]], in which a patient undergoes an observed fast to cause a hypoglyemic episode, allowing for appropriate blood work to be drawn. In some, the hypoglycemic episode may be reproduced simply after a mixed meal, whereas in others a fast may last up to 72 hours.