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 h English (en)[[Sepsis]], a common cause of hypoglycemia in serious illness, can lead to hypoglycemia through many ways. In a state of sepsis, the body uses large amounts of glucose for energy. Glucose use is further increased by [[cytokine]] production. [[Cytokine]]s are a protein produced by the body in a state of stress, particularly when fighting an infection. [[Cytokine]]s may inhibit glucose production, further decreasing the body's energy stores. Finally, the [[liver]] and [[kidney]]s are sites of glucose production, and in a state of sepsis those organs may not receive enough oxygen, leading to decreased glucose production due to organ damage.