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NameCurrent message text
 h English (en)Increased homocysteine levels suggest tissue folate deficiency, but homocysteine is also affected by vitamin B<sub>12</sub> and vitamin B<sub>6</sub>, renal function, and genetics. One way to differentiate between folate deficiency and vitamin B<sub>12</sub> deficiency is by testing for [[methylmalonic acid]] (MMA) levels. Normal MMA levels indicate folate deficiency and elevated MMA levels indicate vitamin B<sub>12</sub> deficiency. Elevated MMA levels may also be due to the rare metabolic disorder [[combined malonic and methylmalonic aciduria]] (CMAMMA).
 h Japanese (ja)ホモシステイン値の上昇は組織葉酸欠乏を示唆するが、ホモシステインはビタミンB<sub>12</sub>やビタミンB<sub>6</sub>、腎機能、遺伝にも影響される。葉酸欠乏症とビタミンB<sub>12</sub>欠乏症を鑑別する一つの方法は、[[methylmalonic acid/ja|メチルマロン酸]](MMA)レベルの検査である。MMA値が正常であれば葉酸欠乏症を、MMA値が高ければビタミンB<sub>12</sub>欠乏症を示す。MMA値の上昇は、まれな代謝異常[[combined malonic and methylmalonic aciduria/ja|マロン酸・メチルマロン酸複合尿症]](CMAMMA)による場合もある。