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Found 2 translations.
| Name | Current message text |
|---|---|
| h English (en) | Since folate deficiency limits cell division, [[erythropoiesis]] (production of red blood cells) is hindered. This leads to [[megaloblastic anemia]], which is characterized by large, immature red blood cells. This pathology results from persistently thwarted attempts at normal DNA replication, DNA repair, and cell division, and produces abnormally large red cells called megaloblasts (and hypersegmented neutrophils) with abundant cytoplasm capable of RNA and protein synthesis, but with clumping and fragmentation of nuclear chromatin. Some of these large cells, although immature (reticulocytes), are released early from the marrow in an attempt to compensate for the anemia. Both adults and children need folate to make normal red and white blood cells and prevent anemia, which causes fatigue, weakness, and inability to concentrate. |
| h Japanese (ja) | 葉酸欠乏は細胞分裂を制限するため、[[erythropoiesis/ja|赤血球の産生]]が妨げられる。その結果、[[megaloblastic anemia/ja|巨赤芽球性貧血]]を引き起こし、この貧血は大きく未熟な赤血球を特徴とする。この病態は、正常なDNA複製、DNA修復、および細胞分裂の試みが持続的に阻害された結果生じ、RNAおよびタンパク質合成が可能な豊富な細胞質を有するが、核クロマチンの凝集と断片化を伴う、巨赤芽球（および過分化好中球）と呼ばれる異常に大きな赤血球を産生する。これらの大きな細胞の一部は、未熟ではあるが（網状赤血球）、貧血を補おうとして骨髄から早期に放出される。大人も子供も、正常な赤血球と白血球を作り、疲労、脱力感、集中力の欠如を引き起こす貧血を防ぐために葉酸を必要とする。 |