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NameCurrent message text
 h English (en)== Metabolism ==
The biological activity of folate in the body depends upon [[dihydrofolate reductase]] action in the liver which converts folate into [[tetrahydrofolate]] (THF). This action is rate-limiting in humans leading to elevated blood concentrations of unmetabolized folic acid when consumption from dietary supplements and fortified foods nears or exceeds the U.S. [[Dietary Reference Intake#Parameters|Tolerable Upper Intake Level]] of 1,000 μg per day.
 h Japanese (ja)== 代謝 ==
{{Anchor|Metabolism}}
体内での葉酸の生物学的活性は、葉酸を[[tetrahydrofolate/ja|テトラヒドロ葉酸]](THF)に変換する肝臓の[[dihydrofolate reductase/ja|ジヒドロ葉酸還元酵素]]の作用に依存する。この作用はヒトでは律速的であるため、サプリメントや強化食品からの摂取量が米国の[[Dietary Reference Intake/ja#Parameters|耐容上限摂取量レベル]]である1日1,000 μgに近いかそれを超えると、代謝されない葉酸の血中濃度が上昇する。