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Found 2 translations.
| Name | Current message text |
|---|---|
| h English (en) | ====Competitive==== A [[competitive inhibitor]] and substrate cannot bind to the enzyme at the same time. Often competitive inhibitors strongly resemble the real substrate of the enzyme. For example, the drug [[methotrexate]] is a competitive inhibitor of the enzyme [[dihydrofolate reductase]], which catalyzes the reduction of [[folic acid|dihydrofolate]] to tetrahydrofolate. The similarity between the structures of dihydrofolate and this drug are shown in the accompanying figure. This type of inhibition can be overcome with high substrate concentration. In some cases, the inhibitor can bind to a site other than the binding-site of the usual substrate and exert an [[#Allosteric modulation|allosteric effect]] to change the shape of the usual binding-site. |
| h Japanese (ja) | ====競合的==== [[competitive inhibitor/ja|競合的阻害剤]]と基質は同時に酵素に結合できない。多くの場合、競合的阻害剤は酵素の実際の基質によく似ている。例えば、[[methotrexate/ja|メトトレキサート]]という薬物は、[[folic acid/ja|ジヒドロ葉酸]]のテトラヒドロ葉酸への還元を触媒する酵素[[dihydrofolate reductase/ja|ジヒドロ葉酸還元酵素]]の競合的阻害剤である。ジヒドロ葉酸とこの薬物の構造の類似性を添付の図に示す。この種の阻害は高濃度の基質で克服できる。場合によっては、阻害剤が通常の基質の結合部位以外の部位に結合し、通常の結合部位の形状を変化させる[[#Allosteric modulation|アロステリック効果]]を発揮することもある。 |