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NameCurrent message text
 h English (en)==Clinical significance==
===Disease===
[[File:Endocrine disorders world map - DALY - WHO2002.svg|thumb|[[Disability-adjusted life year]] for endocrine disorders per 100,000 inhabitants in 2002:
{{Div col|small=yes|colwidth=10em}}
{{legend|#b3b3b3|No data}}
{{legend|#ffff65|Less than 80}}
{{legend|#fff200|80–160}}
{{legend|#ffdc00|160–240}}
{{legend|#ffc600|240–320}}
{{legend|#ffb000|320–400}}
{{legend|#ff9a00|400–480}}
{{legend|#ff8400|480–560}}
{{legend|#ff6e00|560–640}}
{{legend|#ff5800|640–720}}
{{legend|#ff4200|720–800}}
{{legend|#ff2c00|800–1000}}
{{legend|#cb0000|More than 1000}}
{{div col end}}]]
{{Main|Endocrine diseases}}
[[Endocrine diseases|Diseases of the endocrine system]] are common, including conditions such as [[diabetes mellitus]], [[thyroid]] disease, and [[obesity]].
Endocrine disease is characterized by misregulated hormone release (a productive [[pituitary adenoma]]), inappropriate response to signaling ([[hypothyroidism]]), lack of a gland ([[diabetes mellitus type 1]], diminished [[erythropoiesis]] in [[chronic kidney failure]]), or structural enlargement in a critical site such as the thyroid ([[toxic multinodular goitre]]). Hypofunction of endocrine glands can occur as a result of loss of reserve, hyposecretion, [[agenesis]], atrophy, or active destruction. Hyperfunction can occur as a result of hypersecretion, loss of suppression, [[hyperplasia|hyperplastic]] or [[neoplastic]] change, or hyperstimulation.
 h Japanese (ja)==臨床的意義==
{{Anchor|Clinical significance}}
===疾患===
[[File:Endocrine disorders world map - DALY - WHO2002.svg|thumb|2002年の人口10万人当たりの内分泌疾患による[[Disability-adjusted life year/ja|障害調整生存年]]である:
{{Div col|small=yes|colwidth=10em}}
{{legend|#b3b3b3|No data}}
{{legend|#ffff65|Less than 80}}
{{legend|#fff200|80–160}}
{{legend|#ffdc00|160–240}}
{{legend|#ffc600|240–320}}
{{legend|#ffb000|320–400}}
{{legend|#ff9a00|400–480}}
{{legend|#ff8400|480–560}}
{{legend|#ff6e00|560–640}}
{{legend|#ff5800|640–720}}
{{legend|#ff4200|720–800}}
{{legend|#ff2c00|800–1000}}
{{legend|#cb0000|More than 1000}}
{{div col end}}]]
{{Main/ja|Endocrine diseases/ja}}
[[Endocrine diseases/ja|内分泌系の疾患]]は一般的であり、[[diabetes mellitus/ja|糖尿病]]、[[thyroid/ja|甲状腺]]疾患、[[obesity/ja|肥満]]などの病態が含まれる。
内分泌疾患は、ホルモン分泌の誤調節(産生性の[[pituitary adenoma/ja|下垂体腺腫]])、シグナル伝達に対する不適切な反応([[hypothyroidism/ja|甲状腺機能低下症]])、腺の欠乏([[diabetes mellitus type 1/ja|1型糖尿病]]、[[chronic kidney failure/ja|慢性腎不全]]における[[erythropoiesis/ja|赤血球造血]]の低下)、または甲状腺などの重要部位における構造的腫大([[toxic multinodular goitre/ja|中毒性多結節性甲状腺腫]])によって特徴づけられる。内分泌腺の機能低下は、予備能の喪失、分泌低下、[[agenesis/ja|退行]]、萎縮、または積極的な破壊の結果として起こりうる。機能亢進は、分泌過多、抑制の喪失、[[hyperplasia/ja|過形成]]または[[neoplastic/ja|腫瘍性]]変化、または刺激過多の結果として起こりうる。