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 h English (en)[[DPP-4 inhibitor]]s span diverse structural types. In 2007 few of the most [[potency (pharmacology)|potent]] compounds contain a [[proline]] [[mimetic]] cyanopyrrolidine P1 group. This group enhances the potency, probably due to a transient [[covalent]] trapping of the [[nitrile]] group by the active site Ser630 hydroxyl, leading to delayed dissociation and slow tight binding of certain inhibitors. When these potency enhancements were achieved, some chemical stability issues were noted and more advanced molecules had to be made. To avoid these stability issues, the possibility to exclude the [[nitrile]] group was investigated. Amino acids with [[aryl]] or [[Chemical polarity|polar]] [[side chains]] did not show appreciable [[dipeptidyl peptidase-4 inhibitors|DPP-4 inhibition]] and in fact, all compounds without the nitrile group in this research suffered a 20 to 50-fold loss of potency corresponding to the compounds containing the [[nitrile]] group.
 h Japanese (ja)[[DPP-4 inhibitor/ja|DPP-4阻害剤]]は多様な構造型にまたがっている。2007年には、最も[[potency (pharmacology)/ja|効力]]のある化合物のうち数種類が[[proline/ja|プロリン]][[mimetic/ja|模倣]]シアノピロリジンP1基を含んでいた。この基は、おそらく活性部位Ser630水酸基による[[nitrile/ja|ニトリル]]基の一時的な[[covalent/ja|共有結合]]捕捉によるもので、ある種の阻害剤の解離遅延と緩慢な密結合をもたらす。このような効力の増強が達成されたとき、化学的安定性の問題がいくつか指摘され、より高度な分子を作らなければならなくなった。これらの安定性の問題を回避するために、[[nitrile/ja|ニトリル]]基を除外する可能性が検討された。[[aryl/ja|アリール]]または[[chemical polarity/ja|極性]][[side chains/ja|側鎖]]を持つアミノ酸は、[[nitrile/ja|ニトリル]]基を持たない。ニトリル基を持たない化合物はすべて、ニトリル基を持つ化合物に比べて20倍から50倍も効力が低下した。