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 h English (en)[[Glucagon]] increases [[blood glucose]] levels, and DPP-4 inhibitors reduce glucagon and blood glucose levels. The mechanism of DPP-4 inhibitors is to increase [[incretin]] levels ([[GLP-1]] and [[gastric inhibitory polypeptide|GIP]]), which inhibit [[glucagon]] release, which in turn increases [[insulin]] secretion, decreases gastric emptying, and decreases [[blood glucose]] levels.
 h Japanese (ja)[[Glucagon/ja|グルカゴン]]は[[blood glucose/ja|血糖値]]を上昇させ、DPP-4阻害薬はグルカゴンと血糖値を低下させる。DPP-4阻害薬の機序は、[[incretin/ja|インクレチン]]レベル([[GLP-1/ja|GLP-1]]と[[gastric inhibitory polypeptide/ja|GIP]])を増加させ、[[glucagon/ja|グルカゴン]]放出を阻害し、その結果、[[insulin/ja|インスリン]]分泌を増加させ、胃排出を減少させ、[[blood glucose/ja|血糖値]]を低下させる。