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 h English (en)P450 enzymes have been identified in all [[kingdom (biology)|kingdom]]s of life: [[animal]]s, [[plant]]s, [[fungus|fungi]], [[protist]]s, [[bacteria]], and [[archaea]], as well as in [[virus]]es. However, they are not omnipresent; for example, they have not been found in ''[[Escherichia coli]]''. {{as of|2018}}, more than 300,000 distinct CYP proteins are known.
 h Japanese (ja)P450酵素は、[[animal/ja|動物]]、[[plant/ja|植物]]、[[fungus/ja|菌類]]、[[protist/ja|原生生物]]、[[bacteria/ja|細菌]]、[[archaea/ja|古細菌]]、および[[virus/ja|ウイルス]]のすべての[[kingdom (biology)/ja|界]]で同定されている。例えば、''[[Escherichia coli/ja|大腸菌]]''では見つかっていない。2018年現在、30万以上の異なるCYPタンパク質が知られている。