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h English (en) | == Overview == [[File:Acetyl-CoA-2D_colored.svg|thumb|upright=1.6|Structural diagram of acetyl-CoA: The portion in blue, on the left, is the [[Acetyl|acetyl group]]; the portion in black is [[coenzyme A]].]] The citric acid cycle is a [[metabolic pathway]] that connects [[carbohydrate]], [[fat]], and [[protein]] [[metabolism]]. The [[Chemical reaction|reaction]]s of the cycle are carried out by eight [[enzymes]] that completely oxidize [[acetate]] (a two carbon molecule), in the form of acetyl-CoA, into two molecules each of carbon dioxide and water. Through [[catabolism]] of sugars, fats, and proteins, the two-carbon organic product acetyl-CoA is produced which enters the citric acid cycle. The reactions of the cycle also convert three equivalents of [[nicotinamide adenine dinucleotide]] (NAD<sup>+</sup>) into three equivalents of reduced [[Nicotinamide adenine dinucleotide|NAD<sup>+</sup>]] (NADH), one equivalent of [[flavin adenine dinucleotide]] (FAD) into one equivalent of [[Flavin adenine dinucleotide|FADH<sub>2</sub>]], and one equivalent each of [[guanosine diphosphate]] (GDP) and inorganic [[phosphate]] (P<sub>i</sub>) into one equivalent of [[guanosine triphosphate]] (GTP). The NADH and FADH<sub>2</sub> generated by the citric acid cycle are, in turn, used by the [[oxidative phosphorylation]] pathway to generate energy-rich ATP. |
h Japanese (ja) | == 概要 == {{Anchor|Overview}} [[File:Acetyl-CoA-2D_colored.svg|thumb|upright=1.6|アセチル-CoAの構造図: 左側の青い部分が[[Acetyl/ja|アセチル基]]、黒い部分が[[coenzyme A/ja|補酵素A]]である。]] クエン酸サイクルは、[[carbohydrate/ja|炭水化物]]、[[fat/ja|脂肪]]、[[protein/ja|タンパク質]]をつなぐ[[metabolic pathwary/ja|代謝経路]]である。このサイクルの[[Chemical reaction/ja|反応]]は8つの[[enzymes/ja|酵素]]によって行われ、[[acetate/ja|酢酸]](炭素数2の分子)をアセチル-CoAの形で完全に酸化し、それぞれ2分子の二酸化炭素と水にする。糖、脂肪、タンパク質の[[catabolism/ja|異化]]によって、炭素数2の有機生成物アセチル-CoAが生成され、クエン酸サイクルに入る。サイクルの反応はまた、3当量の[[nicotinamide adenine dinucleotide/ja|ニコチンアミドアデニンジヌクレオチド]](NAD<sup>+</sup>)を3当量の還元型[[Nicotinamide adenine dinucleotide/ja|NAD<sup>+</sup>]](NADH)に変換する、 [[flavin adenine dinucleotide/ja|フラビンアデニンジヌクレオチド]](FAD)を1当量の[[Flavin adenine dinucleotide/ja|FADH<sub>2</sub>]]に、[[guanosine diphosphate/ja|グアノシン二リン酸]](GDP)と無機[[phosphate/ja|リン酸]](P<sub>i</sub>)をそれぞれ1当量の[[guanosine triphosphate/ja|グアノシン三リン酸]](GTP)に変換する。クエン酸サイクルによって生成されたNADHとFADH<sub>2</sub>は、[[oxidative phosphorylation/ja|酸化的リン酸化]]経路によってエネルギー豊富なATPを生成するために使われる。 |