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| h English (en) | {{short description|Chemical compound}} {{chembox | Verifiedfields = changed | verifiedrevid = 480474501 | ImageFile = Calcidiol2.svg | ImageAlt = Skeletal formula of calcifediol | ImageFile1 = Calcifediol 3D ball.png | ImageAlt1 = Ball-and-stick model of the calcifediol molecule | PIN = (1''S'',3''Z'')-3-[(2''E'')-2-<nowiki/>{(1''R'',3a''S'',7a''R'')-1-[(2''R'')-6-Hydroxy-6-methylheptan-2-yl]-7a-methyloctahydro-4''H''-inden-4-ylidene}ethylidene]-4-methylidenecyclohexan-1-ol | OtherNames = 25-Hydroxyvitamin D3<br>25-Hydroxycholecalciferol<br>Calcidiol |Section1={{Chembox Identifiers | IUPHAR_ligand = 6921 | ChEBI_Ref = {{ebicite|changed|EBI}} | ChEBI = 17933 | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 1222 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = T0WXW8F54E | KEGG = C01561 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 4446820 | SMILES = O[C@@H]1CC(\C(=C)CC1)=C\C=C2/CCC[C@]3([C@H]2CC[C@@H]3[C@H](C)CCCC(O)(C)C)C | InChI = 1/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1 | InChIKey = JWUBBDSIWDLEOM-DTOXIADCBI | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1 | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = JWUBBDSIWDLEOM-DTOXIADCSA-N | CASNo_Ref = {{cascite|correct|CAS}} | CASNo = 19356-17-3 | PubChem = 5283731 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = DB00146 | MeSHName = Calcifediol }} |Section2={{Chembox Properties | Formula = C<sub>27</sub>H<sub>44</sub>O<sub>2</sub> | MolarMass = 400.64 g/mol | Appearance = | Density = | MeltingPt = | BoilingPt = }} | Section6 = {{Chembox Pharmacology | Pharmacology_ref = | ATCCode_prefix = H05 | ATCCode_suffix = BX05 <!-- Oral formulations only indicated in treatment of renal secondary hyperparathyroidism --> | ATC_Supplemental = | ATCvet = | Licence_EU = | INN = | INN_EMA = | Licence_US = | Legal_status = | Legal_AU = | Legal_AU_comment = | Legal_CA = | Legal_CA_comment = | Legal_NZ = | Legal_NZ_comment = | Legal_UK = | Legal_UK_comment = | Legal_US = | Legal_US_comment = | Legal_EU = | Legal_EU_comment = | Legal_UN = | Legal_UN_comment = | Pregnancy_category = | Pregnancy_AU = | Pregnancy_AU_comment = | Dependence_liability = | AdminRoutes = | Bioavail = | ProteinBound = | Metabolism = | Metabolites = | OnsetOfAction = | HalfLife = | DurationOfAction = | Excretion = }} |Section7={{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }} }} '''Calcifediol''', also known as '''calcidiol''', '''25-hydroxycholecalciferol''', or '''25-hydroxyvitamin D<sub>3</sub>''' (abbreviated '''25(OH)D<sub>3</sub>'''), is a form of [[vitamin D]] produced in the [[liver]] by [[hydroxylation]] of [[vitamin D3|vitamin D<sub>3</sub>]] (cholecalciferol) by the enzyme [[vitamin D 25-hydroxylase]]. Calcifediol can be further hydroxylated by the [[enzyme]] [[25-Hydroxyvitamin D3 1-alpha-hydroxylase|25(OH)D-1α-hydroxylase]], primarily in the kidney, to form [[calcitriol]] (1,25-(OH)<sub>2</sub>D<sub>3</sub>), which is the active hormonal form of vitamin D. |
| h Japanese (ja) | {{chembox | Verifiedfields = changed | verifiedrevid = 480474501 | ImageFile = Calcidiol2.svg | ImageAlt = カルシフェジオールの骨格式 | ImageFile1 = Calcifediol 3D ball.png | ImageAlt1 = カルシフェジオール分子のボール＆スティックモデル | PIN = (1''S'',3''Z'')-3-[(2''E'')-2-<nowiki/>{(1''R'',3a''S'',7a''R'')-1-[(2''R'')-6-Hydroxy-6-methylheptan-2-yl]-7a-methyloctahydro-4''H''-inden-4-ylidene}ethylidene]-4-methylidenecyclohexan-1-ol | OtherNames = 25-Hydroxyvitamin D3<br>25-Hydroxycholecalciferol<br>Calcidiol |Section1={{Chembox Identifiers | IUPHAR_ligand = 6921 | ChEBI_Ref = {{ebicite|changed|EBI}} | ChEBI = 17933 | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 1222 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = T0WXW8F54E | KEGG = C01561 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 4446820 | SMILES = O[C@@H]1CC(\C(=C)CC1)=C\C=C2/CCC[C@]3([C@H]2CC[C@@H]3[C@H](C)CCCC(O)(C)C)C | InChI = 1/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1 | InChIKey = JWUBBDSIWDLEOM-DTOXIADCBI | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1 | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = JWUBBDSIWDLEOM-DTOXIADCSA-N | CASNo_Ref = {{cascite|correct|CAS}} | CASNo = 19356-17-3 | PubChem = 5283731 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = DB00146 | MeSHName = Calcifediol }} |Section2={{Chembox Properties | Formula = C<sub>27</sub>H<sub>44</sub>O<sub>2</sub> | MolarMass = 400.64 g/mol | Appearance = | Density = | MeltingPt = | BoilingPt = }} | Section6 = {{Chembox Pharmacology | Pharmacology_ref = | ATCCode_prefix = H05 | ATCCode_suffix = BX05 <!-- Oral formulations only indicated in treatment of renal secondary hyperparathyroidism --> | ATC_Supplemental = | ATCvet = | Licence_EU = | INN = | INN_EMA = | Licence_US = | Legal_status = | Legal_AU = | Legal_AU_comment = | Legal_CA = | Legal_CA_comment = | Legal_NZ = | Legal_NZ_comment = | Legal_UK = | Legal_UK_comment = | Legal_US = | Legal_US_comment = | Legal_EU = | Legal_EU_comment = | Legal_UN = | Legal_UN_comment = | Pregnancy_category = | Pregnancy_AU = | Pregnancy_AU_comment = | Dependence_liability = | AdminRoutes = | Bioavail = | ProteinBound = | Metabolism = | Metabolites = | OnsetOfAction = | HalfLife = | DurationOfAction = | Excretion = }} |Section7={{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }} }} カルシフェジオール（'''Calcifediol'''）は、'''カルシジオール'''、'''25-ヒドロキシコレカルシフェロール'''、または'''25-ヒドロキシビタミンD<sub>3</sub>'''（略称'''25(OH)D<sub>3</sub>'''）としても知られている、 は、[[vitamin D3/ja|ビタミンD<sub>3</sub>]]（コレカルシフェロール）が酵素[[vitamin D 25-hydroxylase/ja|ビタミンD 25-水酸化酵素]]によって[[liver/ja|肝臓]]で[[hydroxylation/ja|水酸化]]されることによって生成される[[ビタミンD]]の一種である。カルシフェジオールは[[enzyme/ja|酵素]]によってさらに水酸化される。主に腎臓に存在する[[25-Hydroxyvitamin D3 1-alpha-hydroxylase/ja|25(OH)D-1α-ヒドロキシラーゼ]]によってさらに水酸化され、活性型ビタミンDである[[calcitriol/ja|カルシトリオール]]（1,25-(OH)<sub>2</sub>D<sub>3</sub>）となる。 |