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Found 2 translations.
| Name | Current message text |
|---|---|
| h English (en) | {| class="wikitable" |+ Table 1: Comparison of ARB [[pharmacokinetics]] |- ! Drug ! Trade name ! [[Biological half-life]] [hrs] ! [[Cmax_(pharmacology)|Peak plasma concentration [Tmax] ]] ! [[Protein binding]] [%] ! [[Bioavailability]] [%] ! Renal/hepatic [[Clearance (medicine)|clearance]] [%] ! Food effect ! Daily dosage [mg] ! [[Metabolism]]/[[Transport protein|transporter]] |- | [[Losartan]] | Cozaar | 2 h | 1 hr | 98.7% | 33% | 10/90% | Minimal | 50–100 | [[Sensitive substrates]]: [[CYP2C9]] and [[CYP3A4]] |- | [[Losartan#Pharmacokinetics|EXP 3174]] active metabolite of losartan | - | 6–9 hrs | 3–4 hrs after oral losartan administration | 99.8% | – | 50/50% | – | – | AUC reduced by phenytoin and rifampin by 63% and 40% respectively; specific CYP450 isozymes are unknown |- | [[Candesartan]] | Atacand | 9 | 3–4 hrs | >99% | 15% | 60/40% | No | 4–32 |
| h Japanese (ja) | {| class="wikitable" |+ 表1: ARB[[pharmacokinetics/ja|薬物動態]]の比較 |- ! 薬剤 ! 製品名 ! [[Biological half-life/ja|半減期]] [時間] ! [[Cmax_(pharmacology)/ja|ピーク血漿中濃度[Tmax]]] ! [[Protein binding/ja|タンパク質結合率]] [%] ! [[Bioavailability/ja|生物学的利用能]] [%] ! 腎／肝[[Clearance (medicine)/ja|クリアランス]] [%] ! 食べ物の影響 ! 容量/日 [mg] ! [[Metabolism/ja|代謝]]/[[Transport protein/ja|トランスポーター]] |- | [[Losartan/ja|ロサルタン]] | Cozaar | 2H | 1H | 98.7% | 33% | 10/90% | ミネラル | 50–100 | [[Sensitive substrates/ja|センシティブ基質]]: [[CYP2C9/ja|CYP2C9]]と[[CYP3A4/ja|CYP3A4]] |- | [[Losartan/ja#Pharmacokinetics|EXP 3174]] ロサルタンの活性代謝物 | - | 6–9H | ロサルタン経口投与3–4H後 | 99.8% | – | 50/50% | – | – | AUCはフェニトインで63％、リファンピンで40％減少する；特定のCYP450アイソザイムは不明 |- | [[Candesartan/ja|カンデサルタン]] | Atacand | 9 | 3–4H | >99% | 15% | 60/40% | No | 4–32 |