Zinc and the common cold: Difference between revisions

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{{If pagename|Zinc and the common cold='''Zinc supplements'''|other=Zinc supplements}} (frequently [[zinc acetate]] or [[zinc gluconate]] [[Throat lozenge|lozenge]]s) are a group of [[dietary supplements]] that are commonly used for the treatment of the {{no selflink|common cold}}. The use of zinc supplements at doses in excess of 75 mg/day within 24 hours of the onset of symptoms has been shown to reduce the duration of cold symptoms by about 1 day in adults. Adverse effects with zinc supplements [[Oral administration|by mouth]] include bad taste and [[nausea]]. The [[Nasal administration|intranasal use]] of zinc-containing [[nasal spray]]s has been associated with the [[anosmia|loss of the sense of smell]]; consequently, in June 2009, the [[United States Food and Drug Administration]] (USFDA) warned consumers to stop using intranasal zinc.

The [[human rhinovirus]] – the most common [[Viral disease|viral pathogen]] in humans – is the predominant cause of the common cold.<ref name=CDC2015Full>{{cite web|title=Common Cold and Runny Nose|url=https://www.cdc.gov/getsmart/community/for-patients/common-illnesses/colds.html|publisher=United States Centers for Disease Control and Prevention|access-date=January 7, 2018|date=September 26, 2017}}</ref> The hypothesized [[mechanism of action]] by which zinc reduces the severity and/or duration of cold symptoms is the suppression of nasal [[inflammation]] and the direct inhibition of [[Rhinovirus#Pathogenesis|rhinoviral receptor binding]] and rhinoviral [[Viral replication|replication]] in the [[nasal mucosa]].~~<ref name="NIH Zinc" />~~

The [[human rhinovirus]] – the most common [[Viral disease|viral pathogen]] in humans – is the predominant cause of the common cold. The hypothesized [[mechanism of action]] by which zinc reduces the severity and/or duration of cold symptoms is the suppression of nasal [[inflammation]] and the direct inhibition of [[Rhinovirus#Pathogenesis|rhinoviral receptor binding]] and rhinoviral [[Viral replication|replication]] in the [[nasal mucosa]].

== Effectiveness ==

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 {{If pagename|Zinc and the common cold='''Zinc supplements'''|other=Zinc supplements}} (frequently [[zinc acetate]] or [[zinc gluconate]] [[Throat lozenge|lozenge]]s) are a group of [[dietary supplements]] that are commonly used for the treatment of the {{no selflink|common cold}}. The use of zinc supplements at doses in excess of 75&nbsp;mg/day within 24&nbsp;hours of the onset of symptoms has been shown to reduce the duration of cold symptoms by about 1&nbsp;day in adults. Adverse effects with zinc supplements [[Oral administration|by mouth]] include bad taste and [[nausea]]. The [[Nasal administration|intranasal use]] of zinc-containing [[nasal spray]]s has been associated with the [[anosmia|loss of the sense of smell]]; consequently, in June 2009, the [[United States Food and Drug Administration]] (USFDA) warned consumers to stop using intranasal zinc.
-The [[human rhinovirus]]&nbsp;– the most common [[Viral disease|viral pathogen]] in humans&nbsp;– is the predominant cause of the common cold.<ref name=CDC2015Full>{{cite web|title=Common Cold and Runny Nose|url=https://www.cdc.gov/getsmart/community/for-patients/common-illnesses/colds.html|publisher=United States Centers for Disease Control and Prevention|access-date=January 7, 2018|date=September 26, 2017}}</ref> The hypothesized [[mechanism of action]] by which zinc reduces the severity and/or duration of cold symptoms is the suppression of nasal [[inflammation]] and the direct inhibition of [[Rhinovirus#Pathogenesis|rhinoviral receptor binding]] and rhinoviral [[Viral replication|replication]] in the [[nasal mucosa]].<ref name="NIH Zinc" />
+The [[human rhinovirus]]&nbsp;– the most common [[Viral disease|viral pathogen]] in humans&nbsp;– is the predominant cause of the common cold. The hypothesized [[mechanism of action]] by which zinc reduces the severity and/or duration of cold symptoms is the suppression of nasal [[inflammation]] and the direct inhibition of [[Rhinovirus#Pathogenesis|rhinoviral receptor binding]] and rhinoviral [[Viral replication|replication]] in the [[nasal mucosa]].
 == Effectiveness ==