Dihydrofolic acid/ja: Difference between revisions
Dihydrofolic acid/ja
Created page with "2007年末現在、このクラスの酵素については3つの構造が解明されており、PDBのアクセッションコードは{{PDB link|1W78}}、{{PDB link|1W7K}}、{{PDB link|2BMB}}である。" Tags: Mobile edit Mobile web edit |
Created page with "Category:EC 6.3.2 Category:Enzymes of known structure" Tags: Mobile edit Mobile web edit |
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2007年末現在、このクラスの酵素については3つの[[tertiary structure/ja|構造]]が解明されており、[[Protein Data Bank/ja|PDB]]のアクセッションコードは{{PDB link|1W78}}、{{PDB link|1W7K}}、{{PDB link|2BMB}}である。 | 2007年末現在、このクラスの酵素については3つの[[tertiary structure/ja|構造]]が解明されており、[[Protein Data Bank/ja|PDB]]のアクセッションコードは{{PDB link|1W78}}、{{PDB link|1W7K}}、{{PDB link|2BMB}}である。 | ||
==参照== | |||
* {{cite journal | vauthors = GRIFFIN MJ, BROWN GM | title = The Biosynthesis of Folic Acid. III. Enzymatic Formation of Dihydrofolic Acid from Dihydropteroic Acid and of Tetrahydropteroylpolyglutamic Acid Compounds from Tetrahydrofolic Acid | date = 1964 | journal = J. Biol. Chem. | volume = 239 | pages = 310–6 | doi = 10.1016/S0021-9258(18)51783-X | pmid = 14114858 | doi-access = free }} | * {{cite journal | vauthors = GRIFFIN MJ, BROWN GM | title = The Biosynthesis of Folic Acid. III. Enzymatic Formation of Dihydrofolic Acid from Dihydropteroic Acid and of Tetrahydropteroylpolyglutamic Acid Compounds from Tetrahydrofolic Acid | date = 1964 | journal = J. Biol. Chem. | volume = 239 | pages = 310–6 | doi = 10.1016/S0021-9258(18)51783-X | pmid = 14114858 | doi-access = free }} | ||
* {{cite journal | vauthors = Bognar AL, Osborne C, Shane B, Singer SC, Ferone R | date = 1985 | title = Folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase Cloning and high expression of the Escherichia coli folC gene and purification and properties of the gene product | journal = J. Biol. Chem. | volume = 260 | pages = 5625–30 | pmid = 2985605 | issue = 9 | doi = 10.1016/S0021-9258(18)89069-X | doi-access = free }} | * {{cite journal | vauthors = Bognar AL, Osborne C, Shane B, Singer SC, Ferone R | date = 1985 | title = Folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase Cloning and high expression of the Escherichia coli folC gene and purification and properties of the gene product | journal = J. Biol. Chem. | volume = 260 | pages = 5625–30 | pmid = 2985605 | issue = 9 | doi = 10.1016/S0021-9258(18)89069-X | doi-access = free }} | ||
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* {{cite journal | vauthors = Cherest H, Thomas D, Surdin-Kerjan Y | date = 2000 | title = Polyglutamylation of folate coenzymes is necessary for methionine biosynthesis and maintenance of intact mitochondrial genome in Saccharomyces cerevisiae | journal = J. Biol. Chem. | volume = 275 | pages = 14056–63 | pmid = 10799479 | doi = 10.1074/jbc.275.19.14056 | issue = 19 | doi-access = free }} | * {{cite journal | vauthors = Cherest H, Thomas D, Surdin-Kerjan Y | date = 2000 | title = Polyglutamylation of folate coenzymes is necessary for methionine biosynthesis and maintenance of intact mitochondrial genome in Saccharomyces cerevisiae | journal = J. Biol. Chem. | volume = 275 | pages = 14056–63 | pmid = 10799479 | doi = 10.1074/jbc.275.19.14056 | issue = 19 | doi-access = free }} | ||
* {{cite journal | vauthors = Cossins EA, Chen L | date = 1997 | title = Folates and one-carbon metabolism in plants and fungi | journal = [[Phytochemistry (journal)|Phytochemistry]] | volume = 45 | pages = 437–52 | pmid = 9190084 | doi = 10.1016/S0031-9422(96)00833-3 | issue = 3 }} | * {{cite journal | vauthors = Cossins EA, Chen L | date = 1997 | title = Folates and one-carbon metabolism in plants and fungi | journal = [[Phytochemistry (journal)|Phytochemistry]] | volume = 45 | pages = 437–52 | pmid = 9190084 | doi = 10.1016/S0031-9422(96)00833-3 | issue = 3 }} | ||
{{Ligases CO CS and CN/ja}} | |||
{{Ligases CO CS and CN}} | {{Enzymes/ja}} | ||
{{Enzymes}} | |||
{{Portal bar|Biology|border=no}} | {{Portal bar|Biology|border=no}} | ||
[[Category:EC 6.3.2]] | [[Category:EC 6.3.2]] | ||
[[Category:Enzymes of known structure]] | [[Category:Enzymes of known structure]] | ||
Latest revision as of 16:24, 5 April 2024
| ジヒドロ葉酸合成酵素 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 ジヒドロ葉酸合成酵素モノマー, 大腸菌 | |||||||||
| Identifiers | |||||||||
| EC no. | 6.3.2.12 | ||||||||
| CAS no. | 37318-62-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
酵素学において、ジヒドロ葉酸合成酵素（EC 6.3.2.12）は、化学反応を触媒する酵素である。
- ATP + 7,8-dihydropteroate + L-glutamate ADP + phosphate + 7,8-dihydropteroylglutamate
この酵素の3つの基質はATP、7,8-ジヒドロテロエート、L-グルタミン酸であり、3つの産物はADP、リン酸、7,8-ジヒドロテロイルグルタミン酸である。
この酵素はリガーゼのファミリーに属し、特に酸-D-アミノ酸リガーゼ（ペプチド合成酵素）として炭素-窒素結合を形成する。 この酵素クラスの|系統名は7,8-ジヒドロテロエート:L-グルタミン酸リガーゼ（ADP形成）である。その他の一般的な名称としては、ジヒドロ葉酸合成酵素、7,8-ジヒドロ葉酸合成酵素、H2-葉酸合成酵素、7,8-ジヒドロテロエート、L-グルタミン酸リガーゼ（ADP）、ジヒドロ葉酸合成酵素-フォリルポリグルタミン酸合成酵素、フォリルポリ-（γ-グルタミン酸）合成酵素-ジヒドロ葉酸合成酵素、FHFS、FHFS/FPGS、ジヒドロテロエート： L-グルタミン酸リガーゼ（ADP形成）、DHFSなどがある。 この酵素は葉酸生合成に関与している。
構造研究
2007年末現在、このクラスの酵素については3つの構造が解明されており、PDBのアクセッションコードは1W78、1W7K、2BMBである。
参照
- GRIFFIN MJ, BROWN GM (1964). "The Biosynthesis of Folic Acid. III. Enzymatic Formation of Dihydrofolic Acid from Dihydropteroic Acid and of Tetrahydropteroylpolyglutamic Acid Compounds from Tetrahydrofolic Acid". J. Biol. Chem. 239: 310–6. doi:10.1016/S0021-9258(18)51783-X. PMID 14114858.
- Bognar AL, Osborne C, Shane B, Singer SC, Ferone R (1985). "Folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase Cloning and high expression of the Escherichia coli folC gene and purification and properties of the gene product". J. Biol. Chem. 260 (9): 5625–30. doi:10.1016/S0021-9258(18)89069-X. PMID 2985605.
- R, Rebeille F; Cherest, H; Jabrin, S; Grunwald, D; Surdin-Kerjan, Y; Douce, R; Rébeillé, F (2001). "Tetrahydrofolate biosynthesis in plants: molecular and functional characterization of dihydrofolate synthetase and three isoforms of folylpolyglutamate synthetase in Arabidopsis thaliana". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 15360–5. Bibcode:2001PNAS...9815360R. doi:10.1073/pnas.261585098. PMC 65034. PMID 11752472.
- Cherest H, Thomas D, Surdin-Kerjan Y (2000). "Polyglutamylation of folate coenzymes is necessary for methionine biosynthesis and maintenance of intact mitochondrial genome in Saccharomyces cerevisiae". J. Biol. Chem. 275 (19): 14056–63. doi:10.1074/jbc.275.19.14056. PMID 10799479.
- Cossins EA, Chen L (1997). "Folates and one-carbon metabolism in plants and fungi". Phytochemistry. 45 (3): 437–52. doi:10.1016/S0031-9422(96)00833-3. PMID 9190084.