GLP1 poly-agonist peptides: Difference between revisions
Created page with "'''GLP1 poly-agonist peptides''' are a class of drugs that activate multiple peptide hormone receptors including the glucagon-like peptide-1 (GLP-1) receptor. These drugs are developed for the same indications as GLP-1 receptor agonists—especially obesity, type 2 diabetes, and non-alcoholic fatty liver disease. They are expected to provide superior efficacy with fewer adverse effects compared to GLP-1 mono-agonists, which ar..." |
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'''GLP1 poly-agonist peptides''' are a class of drugs that activate multiple [[peptide hormone]] receptors including the [[glucagon-like peptide-1 receptor|glucagon-like peptide-1 (GLP-1) receptor]]. These drugs are developed for the same indications as [[GLP-1 receptor agonist]]s—especially obesity, type 2 diabetes, and non-alcoholic fatty liver disease. They are expected to provide superior efficacy with fewer adverse effects compared to GLP-1 mono-agonists, which are dose-limited by gastrointestinal disturbances. The effectiveness of multi-receptor agonists could possibly equal or exceed that of [[bariatric surgery]]. The first such drug to receive approval is [[tirzepatide]], a dual agonist of GLP-1 and [[GIP receptor]]s. | '''GLP1 poly-agonist peptides''' are a class of drugs that activate multiple [[peptide hormone]] receptors including the [[glucagon-like peptide-1 receptor|glucagon-like peptide-1 (GLP-1) receptor]]. These drugs are developed for the same indications as [[GLP-1 receptor agonist]]s—especially obesity, type 2 diabetes, and non-alcoholic fatty liver disease. They are expected to provide superior efficacy with fewer adverse effects compared to GLP-1 mono-agonists, which are dose-limited by gastrointestinal disturbances. The effectiveness of multi-receptor agonists could possibly equal or exceed that of [[bariatric surgery]]. The first such drug to receive approval is [[tirzepatide]], a dual agonist of GLP-1 and [[GIP receptor]]s. | ||
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[[Category:GLP-1 receptor agonists]] | [[Category:GLP-1 receptor agonists]] | ||
[[Category:Peptide therapeutics]] | [[Category:Peptide therapeutics]] | ||
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