Telmisartan: Difference between revisions
Created page with "{{Short description|Angiotensin II receptor antagonist}} {{Drugbox | Watchedfields = changed | verifiedrevid = 477861448 | image = Telmisartan.svg | width = 220 | alt = <!-- Clinical data --> | pronounce = {{IPAc-en|t|ɛ|l|m|ɪ|ˈ|s|ɑr|t|ən}} | tradename = Micardis, Actavis, others | Drugs.com = {{drugs.com|monograph|telmisartan}} | MedlinePlus = a601249 | DailyMedID = Telmisartan | pregnancy_AU = D | routes_of_administration = By mouth | cla..." |
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Common side effects include [[upper respiratory tract infections]], diarrhea, and back pain. Serious side effects may include [[kidney problems]], [[low blood pressure]], and [[angioedema]]. | Common side effects include [[upper respiratory tract infections]], diarrhea, and back pain. Serious side effects may include [[kidney problems]], [[low blood pressure]], and [[angioedema]]. Use in [[pregnancy]] may harm the baby and use when [[breastfeeding]] is not recommended. It is an [[angiotensin II receptor antagonist]] and works by blocking the effects of [[angiotensin II]]. | ||
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==Medical uses== | ==Medical uses== | ||
Telmisartan is used to treat [[hypertension|high blood pressure]], [[heart failure]], and [[diabetic kidney disease]]. | Telmisartan is used to treat [[hypertension|high blood pressure]], [[heart failure]], and [[diabetic kidney disease]]. It is a reasonable initial treatment for high blood pressure. | ||
==Contraindications== | ==Contraindications== | ||
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Telmisartan is an angiotensin II receptor blocker that shows high affinity for the [[angiotensin II receptor type 1]] (AT<sub>1</sub>), with a binding affinity 3000 times greater for AT<sub>1</sub> than [[Angiotensin II receptor type 2|AT<sub>2</sub>]]. | Telmisartan is an angiotensin II receptor blocker that shows high affinity for the [[angiotensin II receptor type 1]] (AT<sub>1</sub>), with a binding affinity 3000 times greater for AT<sub>1</sub> than [[Angiotensin II receptor type 2|AT<sub>2</sub>]]. | ||
In addition to blocking the [[renin–angiotensin system]], telmisartan acts as a selective modulator of [[peroxisome proliferator-activated receptor gamma]] (PPAR-γ), a central regulator of [[insulin]] and [[glucose]] metabolism. It is believed that telmisartan's dual mode of action may provide protective benefits against the vascular and renal damage caused by [[diabetes]] and [[cardiovascular disease]] (CVD). | In addition to blocking the [[renin–angiotensin system]], telmisartan acts as a selective modulator of [[peroxisome proliferator-activated receptor gamma]] (PPAR-γ), a central regulator of [[insulin]] and [[glucose]] metabolism. It is believed that telmisartan's dual mode of action may provide protective benefits against the vascular and renal damage caused by [[diabetes]] and [[cardiovascular disease]] (CVD). | ||
Telmisartan's activity at the [[peroxisome proliferator-activated receptor delta]] (PPAR-δ) receptor has prompted speculation around its potential as a sport doping agent as an alternative to [[GW 501516]]. Telmisartan activates PPAR-δ receptors in several tissues. | Telmisartan's activity at the [[peroxisome proliferator-activated receptor delta]] (PPAR-δ) receptor has prompted speculation around its potential as a sport doping agent as an alternative to [[GW 501516]]. Telmisartan activates PPAR-δ receptors in several tissues. | ||
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==Society and culture== | ==Society and culture== | ||
Telmisartan is available as a [[generic medication]]. | Telmisartan is available as a [[generic medication]]. | ||
== Further reading == | == Further reading == | ||