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Angiotensin II receptor blocker/ja: Difference between revisions

Angiotensin II receptor blocker/ja
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Created page with "==薬物動態の比較== {{Anchor|Pharmacokinetics comparison}}"
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Created page with "{| class="wikitable" |+ 表1: ARB薬物動態の比較 |- ! 薬剤 ! 製品名 ! 半減期 [時間] ! ピーク血漿中濃度[Tmax] ! タンパク質結合率 [%] ! 生物学的利用能 [%] ! 腎／肝クリアランス [%] ! 食べ物の影響 ! 容量/日 [mg] ! 代謝/Transport protein/ja|トラ..."
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{{Anchor|Pharmacokinetics comparison}}
{{Anchor|Pharmacokinetics comparison}}


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{| class="wikitable"
{| class="wikitable"
|+ Table 1: Comparison of ARB [[pharmacokinetics]]
|+ 表1: ARB[[pharmacokinetics/ja|薬物動態]]の比較
|-
|-
! Drug
! 薬剤
! Trade name
! 製品名
! [[Biological half-life]] [hrs]
! [[Biological half-life/ja|半減期]] [時間]
! [[Cmax_(pharmacology)|Peak plasma concentration [Tmax] ]]
! [[Cmax_(pharmacology)/ja|ピーク血漿中濃度[Tmax]]]
! [[Protein binding]] [%]
! [[Protein binding/ja|タンパク質結合率]] [%]
! [[Bioavailability]] [%]
! [[Bioavailability/ja|生物学的利用能]] [%]
! Renal/hepatic [[Clearance (medicine)|clearance]] [%]
! 腎／肝[[Clearance (medicine)/ja|クリアランス]] [%]
! Food effect
! 食べ物の影響
! Daily dosage [mg]
! 容量/日 [mg]
! [[Metabolism]]/[[Transport protein|transporter]]
! [[Metabolism/ja|代謝]]/[[Transport protein/ja|トランスポーター]]
|-
|-
| [[Losartan]]
| [[Losartan/ja|ロサルタン]]
| Cozaar
| Cozaar
| 2 h
| 2H
| 1 hr
| 1H
| 98.7%
| 98.7%
| 33%
| 33%
| 10/90%
| 10/90%
| Minimal
| ミネラル
| 50–100
| 50–100
| [[Sensitive substrates]]: [[CYP2C9]] and [[CYP3A4]]
| [[Sensitive substrates/ja|センシティブ基質]]: [[CYP2C9/ja|CYP2C9]]と[[CYP3A4/ja|CYP3A4]]
|-
|-
| [[Losartan#Pharmacokinetics|EXP 3174]] active metabolite of losartan
| [[Losartan/ja#Pharmacokinetics|EXP 3174]] ロサルタンの活性代謝物
| -
| -
| 6–9 hrs
| 6–9H
| 3–4 hrs after oral losartan administration
| ロサルタン経口投与3–4H後
| 99.8%
| 99.8%
| –
| –
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| –
| –
| –
| –
| AUC reduced by phenytoin and rifampin by 63% and 40% respectively; specific CYP450 isozymes are unknown
| AUCはフェニトインで63％、リファンピンで40％減少する；特定のCYP450アイソザイムは不明
|-
|-
| [[Candesartan]]
| [[Candesartan/ja|カンデサルタン]]
| Atacand
| Atacand
| 9
| 9
| 3–4 hrs
| 3–4H
| >99%
| >99%
| 15%
| 15%
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| No
| No
| 4–32
| 4–32
</div>


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