Dihydrofolic acid: Difference between revisions

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{{Short description|Class of enzymes}}

{{infobox enzyme

In [[enzymology]], a '''dihydrofolate synthase''' ({{EnzExplorer|6.3.2.12}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:ATP + 7,8-dihydropteroate + L-glutamate <math>\rightleftharpoons</math> ADP + phosphate + 7,8-dihydropteroylglutamate

The 3 [[substrate (biochemistry)|substrates]] of this enzyme are [[adenosine triphosphate|ATP]], [[7,8-dihydropteroate]], and [[L-glutamate]], whereas its 3 [[product (chemistry)|products]] are [[adenosine diphosphate|ADP]], [[phosphate]], and [[7,8-dihydropteroylglutamate]].

This enzyme belongs to the family of [[ligase]]s, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases).  The [[List of enzymes|systematic name]] of this enzyme class is '''7,8-dihydropteroate:L-glutamate ligase (ADP-forming)'''. Other names in common use include '''dihydrofolate synthetase''', '''7,8-dihydrofolate synthetase''', '''H2-folate synthetase''', '''7,8-dihydropteroate:L-glutamate ligase (ADP)''', '''dihydrofolate synthetase-folylpolyglutamate synthetase''', '''folylpoly-(gamma-glutamate) synthetase-dihydrofolate synthase''', '''FHFS''', '''FHFS/FPGS''', '''dihydropteroate:L-glutamate ligase (ADP-forming)''', and '''DHFS'''.  This enzyme participates in [[folate biosynthesis]].

As of late 2007, 3 [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|1W78}}, {{PDB link|1W7K}}, and {{PDB link|2BMB}}.

* {{cite journal | vauthors = GRIFFIN MJ, BROWN GM | title = The Biosynthesis of Folic Acid. III. Enzymatic Formation of Dihydrofolic Acid from Dihydropteroic Acid and of Tetrahydropteroylpolyglutamic Acid Compounds from Tetrahydrofolic Acid | date = 1964 | journal = J. Biol. Chem.  | volume = 239 | pages = 310&ndash;6  | doi = 10.1016/S0021-9258(18)51783-X | pmid = 14114858 | doi-access = free }}

* {{cite journal | vauthors = Bognar AL, Osborne C, Shane B, Singer SC, Ferone R | date = 1985 | title = Folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase Cloning and high expression of the Escherichia coli folC gene and purification and properties of the gene product | journal = J. Biol. Chem.  | volume = 260 | pages = 5625&ndash;30  | pmid = 2985605 | issue = 9 | doi = 10.1016/S0021-9258(18)89069-X | doi-access = free }}

* {{cite journal | vauthors = Cossins EA, Chen L | date = 1997 | title = Folates and one-carbon metabolism in plants and fungi | journal = [[Phytochemistry (journal)|Phytochemistry]]  | volume = 45 | pages = 437&ndash;52  | pmid = 9190084 | doi = 10.1016/S0031-9422(96)00833-3 | issue = 3 }}

{{Ligases CO CS and CN}}

{{Enzymes}}

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{{二次利用|date=26 August 2023}}

[[Category:EC 6.3.2]]

[[Category:Enzymes of known structure]]

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