Translations:Nifedipine/1/en: Difference between revisions

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Message definition (Nifedipine)
{{Pathnav|Medication|Antihypertensive drug|Calcium channel blocker|frame=1}}
{{Short description|Calcium channel blocker medication}}
{{Drugbox
| verifiedrevid = 462260435
| IUPAC_name = 3,5-dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
| imageL = Nifedipine.svg
| imageR = Nifedipine-from-xtal-3D-balls.png
| image2 = Nifedipine_substance_photo.jpg
<!--Clinical data-->
| tradename = Adalat, Procardia, others
| Drugs.com = {{drugs.com|monograph|nifedipine}}
| MedlinePlus = a684028
| DailyMedID = Nifedipine
| pregnancy_AU      = C
| pregnancy_AU_comment = 
| pregnancy_category= 
| legal_status =  
| routes_of_administration = [[Oral administration|By mouth]], topical
| class = [[Calcium channel blocker]] ([[dihydropyridine]])
<!--Pharmacokinetic data-->
| bioavailability = 45-56%
| protein_bound = 92-98%
| metabolism = Gastrointestinal, Liver
| elimination_half-life = 2 hours
| excretion = Kidneys: >50%, Biliary: 5-15%
<!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 21829-25-4
| ATC_prefix = C08
| ATC_suffix = CA05
| ATC_supplemental =  
| PubChem = 4485
| IUPHAR_ligand = 2514
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB01115
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 4330
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = I9ZF7L6G2L
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D00437
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 7565
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 193
<!--Chemical data-->
| C=17 | H=18 | N=2 | O=6
| smiles = O=C(OC)\C1=C(\N/C(=C(/C(=O)OC)C1c2ccccc2[N+]([O-])=O)C)C
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = HYIMSNHJOBLJNT-UHFFFAOYSA-N
| melting_point = 173
}}
<!-- Definition and medical uses -->
'''Nifedipine''', sold under the brand names '''Adalat''' and '''Procardia''' among others, is a [[calcium channel blocker]] medication used to manage [[angina]], [[hypertension|high blood pressure]], [[Raynaud's phenomenon]], and [[premature labor]]. It is one of the treatments of choice for [[Prinzmetal angina]]. It may be used to treat severe [[high blood pressure in pregnancy]]. Its use in preterm labor may allow more time for [[corticosteroid|steroids]] to improve the baby's lung function and provide time for transfer of the mother to a well qualified medical facility before delivery. It is a calcium channel blocker of the [[Dihydropyridine calcium channel blockers|dihydropyridine]] type. Nifedipine is taken by mouth and comes in fast- and slow-release formulations.
Medication > Antihypertensive drug > Calcium channel blocker > Nifedipine/1/en
Nifedipine/1/en
Clinical data
Trade namesAdalat, Procardia, others
AHFS/Drugs.comMonograph
MedlinePlusa684028
License data
Pregnancy
category
  • AU: C
Routes of
administration		By mouth, topical
Drug classCalcium channel blocker (dihydropyridine)
ATC code
Pharmacokinetic data
Bioavailability45-56%
Protein binding92-98%
MetabolismGastrointestinal, Liver
Elimination half-life2 hours
ExcretionKidneys: >50%, Biliary: 5-15%
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
Chemical and physical data
FormulaC17H18N2O6
Molar mass346.339 g·mol−1
3D model (JSmol)
Melting point173 °C (343 °F)
  (verify)

Nifedipine, sold under the brand names Adalat and Procardia among others, is a calcium channel blocker medication used to manage angina, high blood pressure, Raynaud's phenomenon, and premature labor. It is one of the treatments of choice for Prinzmetal angina. It may be used to treat severe high blood pressure in pregnancy. Its use in preterm labor may allow more time for steroids to improve the baby's lung function and provide time for transfer of the mother to a well qualified medical facility before delivery. It is a calcium channel blocker of the dihydropyridine type. Nifedipine is taken by mouth and comes in fast- and slow-release formulations.

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