Translations:Nifedipine/1/en

Medication > Antihypertensive drug > Calcium channel blocker > Nifedipine/1/en

Nifedipine/1/en

Clinical data
Trade names	Adalat, Procardia, others
AHFS/Drugs.com	Monograph
MedlinePlus	a684028
License data	US DailyMed: Nifedipine
Pregnancy category	AU: C
Routes of administration	By mouth, topical
Drug class	Calcium channel blocker (dihydropyridine)
ATC code	C08CA05 (WHO)
Pharmacokinetic data
Bioavailability	45-56%
Protein binding	92-98%
Metabolism	Gastrointestinal, Liver
Elimination half-life	2 hours
Excretion	Kidneys: >50%, Biliary: 5-15%
Identifiers
IUPAC name 3,5-dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
CAS Number	21829-25-4 Y
PubChem CID	4485
IUPHAR/BPS	2514
DrugBank	DB01115 Y
ChemSpider	4330 Y
UNII	I9ZF7L6G2L
KEGG	D00437 Y
ChEBI	CHEBI:7565 Y
ChEMBL	ChEMBL193 Y
Chemical and physical data
Formula	C17H18N2O6
Molar mass	346.339 g·mol−1
3D model (JSmol)	Interactive image
Melting point	173 °C (343 °F)
SMILES O=C(OC)\C1=C(\N/C(=C(/C(=O)OC)C1c2ccccc2[N+]([O-])=O)C)C
InChI InChI=1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3 Y Key:HYIMSNHJOBLJNT-UHFFFAOYSA-N Y
(verify)

Nifedipine, sold under the brand names Adalat and Procardia among others, is a calcium channel blocker medication used to manage angina, high blood pressure, Raynaud's phenomenon, and premature labor. It is one of the treatments of choice for Prinzmetal angina. It may be used to treat severe high blood pressure in pregnancy. Its use in preterm labor may allow more time for steroids to improve the baby's lung function and provide time for transfer of the mother to a well qualified medical facility before delivery. It is a calcium channel blocker of the dihydropyridine type. Nifedipine is taken by mouth and comes in fast- and slow-release formulations.