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Message definition (Collagen ) '''Collagen''' ({{IPAc-en|ˈ|k|ɒ|l|ə|dʒ|ə|n}}) is the main structural [[protein]] in the [[extracellular matrix]] found in the body's various [[connective tissue]]s. As the main component of connective tissue, it is the most abundant protein in mammals, making up from 25% to 35% of the whole-body protein content. Collagen consists of [[amino acid]]s bound together to form a [[triple helix]] of elongated [[fibril]] known as a [[collagen helix]]. It is mostly found in [[connective tissue]] such as [[cartilage]], [[bone]]s, [[tendon]]s, [[ligament]]s, and [[skin]]. [[Vitamin C]] is vital for collagen synthesis, and [[Vitamin E]] improves the production of collagen. [[File:HCR-FISH visualization of collagen expression in P. waltl.jpg|thumb|HCR-[[Fluorescence in situ hybridization|FISH]] visualization of collagen expression in ''[[Pleurodeles waltl|P. waltl]]'']] Depending upon the degree of [[biomineralization|mineralization]], collagen tissues may be rigid (bone) or compliant (tendon) or have a gradient from rigid to compliant (cartilage). Collagen is also abundant in [[cornea]]s, [[blood vessel]]s, the [[Gut (anatomy)|gut]], [[intervertebral disc]]s, and the [[dentin]] in teeth. In [[muscle tissue]], it serves as a major component of the [[endomysium]]. Collagen constitutes one to two percent of muscle tissue and accounts for 6% of the weight of the [[skeletal muscle]] tissue. The [[fibroblast]] is the most common cell that creates collagen. [[Gelatin]], which is used in food and industry, is collagen that has been irreversibly [[hydrolyzed]] using heat, basic solutions or weak acids.
Collagen () is the main structural protein in the extracellular matrix found in the body's various connective tissues . As the main component of connective tissue, it is the most abundant protein in mammals, making up from 25% to 35% of the whole-body protein content. Collagen consists of amino acids bound together to form a triple helix of elongated fibril known as a collagen helix . It is mostly found in connective tissue such as cartilage , bones , tendons , ligaments , and skin . Vitamin C is vital for collagen synthesis, and Vitamin E improves the production of collagen.
HCR-FISH visualization of collagen expression in P. waltl
Depending upon the degree of mineralization , collagen tissues may be rigid (bone) or compliant (tendon) or have a gradient from rigid to compliant (cartilage). Collagen is also abundant in corneas , blood vessels , the gut , intervertebral discs , and the dentin in teeth. In muscle tissue , it serves as a major component of the endomysium . Collagen constitutes one to two percent of muscle tissue and accounts for 6% of the weight of the skeletal muscle tissue. The fibroblast is the most common cell that creates collagen. Gelatin , which is used in food and industry, is collagen that has been irreversibly hydrolyzed using heat, basic solutions or weak acids.