Translations:Calcitriol/14/en: Difference between revisions

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Message definition (Calcitriol)
The major conditions with hypercalcaemia due to elevated calcitriol levels are [[lymphoma]], [[tuberculosis]] and [[sarcoidosis]] where excess production occurs due to ectopic 25(OH)D-1-hydroxylase (CYP27B1) expressed in [[macrophages]].
Other conditions producing similar findings including:
* Fungal infections; Pneumocystis jiroveci, histoplasmosis, coccidioidomycosis, paracoccidioidomycosis, candidiasis
* Other granulomatous conditions; [[Granulomatosis with polyangiitis|PR3+ vasculitis]], [[Crohn's disease]], acute granulomatous pneumonia, talc granuloma, silicone-induced granuloma, BCG-associated, granulomatous hepatitis, paraffin-associated granuloma
* Genetic conditions; Williams syndrome, pseudoxanthoma elasticum, [[CYP24A1|CYP24A1 mutation]] (adult / infantile), SLC34A1 mutation
* Miscellaneous; mycobacterium avium, leprosy, lipoid pneumonia, cat scratch fever, berylliosis

The major conditions with hypercalcaemia due to elevated calcitriol levels are lymphoma, tuberculosis and sarcoidosis where excess production occurs due to ectopic 25(OH)D-1-hydroxylase (CYP27B1) expressed in macrophages. Other conditions producing similar findings including:

  • Fungal infections; Pneumocystis jiroveci, histoplasmosis, coccidioidomycosis, paracoccidioidomycosis, candidiasis
  • Other granulomatous conditions; PR3+ vasculitis, Crohn's disease, acute granulomatous pneumonia, talc granuloma, silicone-induced granuloma, BCG-associated, granulomatous hepatitis, paraffin-associated granuloma
  • Genetic conditions; Williams syndrome, pseudoxanthoma elasticum, CYP24A1 mutation (adult / infantile), SLC34A1 mutation
  • Miscellaneous; mycobacterium avium, leprosy, lipoid pneumonia, cat scratch fever, berylliosis
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