Translations:Ergocalciferol/12/en: Difference between revisions

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Message definition (Ergocalciferol)
Like [[cholecalciferol]], ergocalciferol is inactive by itself. It requires two [[hydroxylation]]s to become active: the first in the liver by [[CYP2R1]] to form 25-hydroxyergocalciferol (ercalcidiol or 25-OH D<sub>2</sub>), and the second in the kidney by [[CYP27B1]], to form the active 1,25-dihydroxyergocalciferol (ercalcitriol or 1,25-(OH)<sub>2</sub>D<sub>2</sub>), which activates the [[vitamin D receptor]]. Unlike [[cholecalciferol]], 25-hydroxylation is not performed by [[CYP27A1]] for ergocalciferol.

Like cholecalciferol, ergocalciferol is inactive by itself. It requires two hydroxylations to become active: the first in the liver by CYP2R1 to form 25-hydroxyergocalciferol (ercalcidiol or 25-OH D2), and the second in the kidney by CYP27B1, to form the active 1,25-dihydroxyergocalciferol (ercalcitriol or 1,25-(OH)2D2), which activates the vitamin D receptor. Unlike cholecalciferol, 25-hydroxylation is not performed by CYP27A1 for ergocalciferol.

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