Translations:Nicotinamide mononucleotide/10/en: Difference between revisions

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Message definition (Nicotinamide mononucleotide)
Certain enzymes are sensitive to the intracellular NMN/[[Nicotinamide adenine dinucleotide|NAD<sup>+</sup>]] ratio, such as [[SARM1]], a protein responsible for initiating cellular degeneration pathways such as [[MAP kinase]] and inducing [[axon|axonal]] loss and [[necrosis|neuronal death]]. [[NMNAT1|NMNAT]] is an enzyme with neurorescuing properties that functions to deplete NMN and produce NAD<sup>+</sup>, attenuating SARM1 activity and aiding neuronal survival ''in-vitro'', an effect that is reversed by applying exogenous NMN which promptly resumed axon destruction. The similar molecule nicotinic acid mononucleotide (NaMN) opposes the activating effect of NMN on [[SARM1]], and is a neuroprotector.

Certain enzymes are sensitive to the intracellular NMN/NAD+ ratio, such as SARM1, a protein responsible for initiating cellular degeneration pathways such as MAP kinase and inducing axonal loss and neuronal death. NMNAT is an enzyme with neurorescuing properties that functions to deplete NMN and produce NAD+, attenuating SARM1 activity and aiding neuronal survival in-vitro, an effect that is reversed by applying exogenous NMN which promptly resumed axon destruction. The similar molecule nicotinic acid mononucleotide (NaMN) opposes the activating effect of NMN on SARM1, and is a neuroprotector.

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