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Dihydrofolic acid/ja: Difference between revisions

Dihydrofolic acid/ja
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:ATP + 7,8-dihydropteroate + L-glutamate <math>\rightleftharpoons</math> ADP + phosphate + 7,8-dihydropteroylglutamate
:ATP + 7,8-dihydropteroate + L-glutamate <math>\rightleftharpoons</math> ADP + phosphate + 7,8-dihydropteroylglutamate


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この酵素の3つの[[substrate (biochemistry)/ja|基質]]は[[adenosine triphosphate/ja|ATP]]、[[7,8-dihydropteroate/ja|7,8-ジヒドロテロエート]]、[[L-glutamate/ja|L-グルタミン酸]]であり、3つの[[product (chemistry)/ja|産物]]は[[adenosine diphosphate/ja|ADP]]、[[phosphate/ja|リン酸]]、[[7,8-dihydropteroylglutamate/ja|7,8-ジヒドロテロイルグルタミン酸]]である。
The 3 [[substrate (biochemistry)|substrates]] of this enzyme are [[adenosine triphosphate|ATP]], [[7,8-dihydropteroate]], and [[L-glutamate]], whereas its 3 [[product (chemistry)|products]] are [[adenosine diphosphate|ADP]], [[phosphate]], and [[7,8-dihydropteroylglutamate]].
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この酵素は[[ligase/ja|リガーゼ]]のファミリーに属し、特に酸-D-アミノ酸リガーゼ（ペプチド合成酵素）として炭素-窒素結合を形成する。 この酵素クラスの[[List of enzymes/ja||系統名]]は'''7,8-ジヒドロテロエート:L-グルタミン酸リガーゼ（ADP形成）'''である。その他の一般的な名称としては、'''ジヒドロ葉酸合成酵素'''、'''7,8-ジヒドロ葉酸合成酵素'''、'''H2-葉酸合成酵素'''、'''7,8-ジヒドロテロエート'''、'''L-グルタミン酸リガーゼ（ADP）'''、'''ジヒドロ葉酸合成酵素-フォリルポリグルタミン酸合成酵素'''、'''フォリルポリ-（γ-グルタミン酸）合成酵素-ジヒドロ葉酸合成酵素'''、'''FHFS'''、'''FHFS/FPGS'''、'''ジヒドロテロエート： L-グルタミン酸リガーゼ（ADP形成）'''、'''DHFS'''などがある。 この酵素は[[folate biosynthesis/ja|葉酸生合成]]に関与している。
This enzyme belongs to the family of [[ligase]]s, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases).  The [[List of enzymes|systematic name]] of this enzyme class is '''7,8-dihydropteroate:L-glutamate ligase (ADP-forming)'''. Other names in common use include '''dihydrofolate synthetase''', '''7,8-dihydrofolate synthetase''', '''H2-folate synthetase''', '''7,8-dihydropteroate:L-glutamate ligase (ADP)''', '''dihydrofolate synthetase-folylpolyglutamate synthetase''', '''folylpoly-(gamma-glutamate) synthetase-dihydrofolate synthase''', '''FHFS''', '''FHFS/FPGS''', '''dihydropteroate:L-glutamate ligase (ADP-forming)''', and '''DHFS'''.  This enzyme participates in [[folate biosynthesis]].
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==構造研究==
==Structural studies==
{{Anchor|Structural studies}}
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2007年末現在、このクラスの酵素については3つの[[tertiary structure/ja|構造]]が解明されており、[[Protein Data Bank/ja|PDB]]のアクセッションコードは{{PDB link|1W78}}、{{PDB link|1W7K}}、{{PDB link|2BMB}}である。
As of late 2007, 3 [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|1W78}}, {{PDB link|1W7K}}, and {{PDB link|2BMB}}.
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==参照==
==References==
* {{cite journal | vauthors = GRIFFIN MJ, BROWN GM | title = The Biosynthesis of Folic Acid. III. Enzymatic Formation of Dihydrofolic Acid from Dihydropteroic Acid and of Tetrahydropteroylpolyglutamic Acid Compounds from Tetrahydrofolic Acid | date = 1964 | journal = J. Biol. Chem.  | volume = 239 | pages = 310&ndash;6  | doi = 10.1016/S0021-9258(18)51783-X | pmid = 14114858 | doi-access = free }}
* {{cite journal | vauthors = GRIFFIN MJ, BROWN GM | title = The Biosynthesis of Folic Acid. III. Enzymatic Formation of Dihydrofolic Acid from Dihydropteroic Acid and of Tetrahydropteroylpolyglutamic Acid Compounds from Tetrahydrofolic Acid | date = 1964 | journal = J. Biol. Chem.  | volume = 239 | pages = 310&ndash;6  | doi = 10.1016/S0021-9258(18)51783-X | pmid = 14114858 | doi-access = free }}
* {{cite journal | vauthors = Bognar AL, Osborne C, Shane B, Singer SC, Ferone R | date = 1985 | title = Folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase Cloning and high expression of the Escherichia coli folC gene and purification and properties of the gene product | journal = J. Biol. Chem.  | volume = 260 | pages = 5625&ndash;30  | pmid = 2985605 | issue = 9 | doi = 10.1016/S0021-9258(18)89069-X | doi-access = free }}
* {{cite journal | vauthors = Bognar AL, Osborne C, Shane B, Singer SC, Ferone R | date = 1985 | title = Folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase Cloning and high expression of the Escherichia coli folC gene and purification and properties of the gene product | journal = J. Biol. Chem.  | volume = 260 | pages = 5625&ndash;30  | pmid = 2985605 | issue = 9 | doi = 10.1016/S0021-9258(18)89069-X | doi-access = free }}
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* {{cite journal | vauthors = Cherest H, Thomas D, Surdin-Kerjan Y | date = 2000 | title = Polyglutamylation of folate coenzymes is necessary for methionine biosynthesis and maintenance of intact mitochondrial genome in Saccharomyces cerevisiae | journal = J. Biol. Chem.  | volume = 275 | pages = 14056&ndash;63  | pmid = 10799479 | doi = 10.1074/jbc.275.19.14056 | issue = 19 | doi-access = free }}
* {{cite journal | vauthors = Cherest H, Thomas D, Surdin-Kerjan Y | date = 2000 | title = Polyglutamylation of folate coenzymes is necessary for methionine biosynthesis and maintenance of intact mitochondrial genome in Saccharomyces cerevisiae | journal = J. Biol. Chem.  | volume = 275 | pages = 14056&ndash;63  | pmid = 10799479 | doi = 10.1074/jbc.275.19.14056 | issue = 19 | doi-access = free }}
* {{cite journal | vauthors = Cossins EA, Chen L | date = 1997 | title = Folates and one-carbon metabolism in plants and fungi | journal = [[Phytochemistry (journal)|Phytochemistry]]  | volume = 45 | pages = 437&ndash;52  | pmid = 9190084 | doi = 10.1016/S0031-9422(96)00833-3 | issue = 3 }}
* {{cite journal | vauthors = Cossins EA, Chen L | date = 1997 | title = Folates and one-carbon metabolism in plants and fungi | journal = [[Phytochemistry (journal)|Phytochemistry]]  | volume = 45 | pages = 437&ndash;52  | pmid = 9190084 | doi = 10.1016/S0031-9422(96)00833-3 | issue = 3 }}
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{{Ligases CO CS and CN/ja}}
{{Ligases CO CS and CN}}
{{Enzymes/ja}}
{{Enzymes}}
{{Portal bar|Biology|border=no}}
{{Portal bar|Biology|border=no}}
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{{二次利用|date=26 August 2023}}
[[Category:EC 6.3.2]]
[[Category:EC 6.3.2]]
[[Category:Enzymes of known structure]]
[[Category:Enzymes of known structure]]
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