Translations:Pyridoxal phosphate/9/ja: Difference between revisions

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Created page with "ピリドキサールリン酸は人体内で数多くの役割を担っている。以下にいくつか例を挙げる： * '''セロトニンの代謝と生合成''' ピリドキサールリン酸は芳香族L-アミノ酸脱炭酸酵素の補要素である。これにより、[[5-Hydroxytryptophan/ja|5-ヒドロキシトリプトファン]..."
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Revision as of 09:05, 4 April 2024

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Message definition (Pyridoxal phosphate)
Pyridoxal phosphate has numerous roles in human body. A few examples below:
* '''[[Metabolism]] and [[biosynthesis]] of [[serotonin]]'''. Pyridoxal phosphate is a [[Cofactor (biochemistry)|cofactor]] of [[Aromatic L-amino acid decarboxylase|aromatic L-amino acids decarboxylase]]. This allows for conversion of  [[5-Hydroxytryptophan|5-hydroxytryptophan]] (5-HTP) into serotonine (5-HT). This reaction takes place in serotonergic neurons.
* '''Metabolism and biosynthesis of [[histamine]].''' Pyridoxal phosphate is a cofactor of [[Histidine decarboxylase|L-histidine decarboxylase]]. This allows for conversion of [[histidine]] into histamine. This reaction takes place in [[Golgi apparatus]] in [[mast cell]]s and in [[basophil]]s. Next, histamine is stored in granularity in mast cells as a complex with acid residues of [[heparin]] proteoglycan while in basophils as a complex with chondroitine sulfate.
* '''Metabolism and biosynthesis of [[Gamma-Aminobutyric acid|GABA]] (γ-aminobutyric acid)'''. Pyridoxal phosphate is a cofactor of glutamic acid decarboxylase (GAD). This allows for conversion of glutamate into GABA. Reaction takes place in cytoplasm of termination of GABA-ergic neurons, therefore [[Vitamin B6|vitamin B<sub>6</sub>]] deficiency may cause epileptic [[Epileptic seizure|seizures]] in children. Pyridoxal phosphate also participates in the oxidative [[Deamidation|deamination]] of GABA, where it is a cofactor of GABA aminotransferase. 
* '''Metabolism of [[ornithine]]'''. Pyridoxal phosphate is a cofactor of ornithine carboxylase.
* '''[[Transamination]].''' Pyridoxal phosphate takes part in [[decomposition]] and synthesis of [[amino acid]]s, fats, and carbohydrates, and in the biosynthesis of hormones, neurotransmitters, and heme.

ピリドキサールリン酸は人体内で数多くの役割を担っている。以下にいくつか例を挙げる：

�ヒスタミンの代謝と合成 ピリドキサールリン酸はL-ヒスチジン脱炭酸酵素の補酵素である。ピリドキサールリン酸はL-ヒスチジン脱炭酸酵素の補酵素である。これにより、ヒスチジンからヒスタミンへの変換が可能になる。この反応は肥満細胞や好塩基球のゴルジ装置で起こる。次に、ヒスタミンは、肥満細胞ではヘパリンプロテオグリカンの酸残基との複合体として、好塩基球ではコンドロイチン硫酸との複合体として顆粒状に貯蔵される。

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