Translations:Pyridoxal phosphate/29/en: Difference between revisions

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Message definition (Pyridoxal phosphate)
==Evolution==
[[Pyridoxal 5-phosphate|Pyridoxal-5-phosphate (vitamin B6)]]-dependent enzymes have multiple evolutionary origins. The overall [[Vitamin B6|B6 enzymes]] diverged into four independent evolutionary lines: α family (i.e. [[Aspartate transaminase|aspartate aminotransferase]]), β family ([[serine dehydratase]]),D-[[alanine aminotransferase]] family and the [[alanine racemase]] family. An example of the evolutionary similarity in the Beta family is seen in the mechanism. The β enzymes are all [[lyase]]s and catalyze reactions where Cα and Cβ participate. Overall, in the [[Vitamin B6|PLP]]-dependent enzymes, the PLP in every case is covalently attached via an imine bond to the amino group in the active site.

Evolution

Pyridoxal-5-phosphate (vitamin B6)-dependent enzymes have multiple evolutionary origins. The overall B6 enzymes diverged into four independent evolutionary lines: α family (i.e. aspartate aminotransferase), β family (serine dehydratase),D-alanine aminotransferase family and the alanine racemase family. An example of the evolutionary similarity in the Beta family is seen in the mechanism. The β enzymes are all lyases and catalyze reactions where Cα and Cβ participate. Overall, in the PLP-dependent enzymes, the PLP in every case is covalently attached via an imine bond to the amino group in the active site.

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